NDLI: Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo.

Please wait, while we are loading the content...

Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.

Does ß-hexosaminidase function only as a degranulation indicator in mast cells? The primary role of ß-hexosaminidase in mast cell granules.

Leukocyte ß7 integrin targeted by Krüppel-like factors.

Structure of the superantigen staphylococcal enterotoxin B in complex with TCR and peptide-MHC demonstrates absence of TCR-peptide contacts.

Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function.

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo.

Marginal zone B cells transport IgG3-immune complexes to splenic follicles.

TRIL is involved in cytokine production in the brain following Escherichia coli infection.

Neutrophils exhibit differential requirements for homing molecules in their lymphatic and blood trafficking into draining lymph nodes.

The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.

NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma.

Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue.

Antigen-specific naive CD8+ T cells produce a single pulse of IFN-Î³ in vivo within hours of infection, but without antiviral effect.

Differential role for p120-catenin in regulation of TLR4 signaling in macrophages.

IL-2 induction of Blimp-1 is a key in vivo signal for CD8+ short-lived effector T cell differentiation.

IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure.

Inhibition of the classical pathway of complement by meningococcal capsular polysaccharides.

Î³Î´T cells drive myeloid-derived suppressor cell-mediated CD8+ T cell exhaustion in hepatitis B virus-induced immunotolerance.

Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses.

Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model.

The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling.

Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcÎ³RIIIB and Mac-1.

The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway.

A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.

Enhancement of adaptive immunity by the human vaccine adjuvant AS01 depends on activated dendritic cells.

Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.

Cutting edge: An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells.

Moderate alcohol induces stress proteins HSF1 and hsp70 and inhibits pro-inflammatory cytokines resulting in endotoxin $tolerance^{}$

Lymph node stromal cells negatively regulate antigen-specific CD4+ T cell responses.

FcÎ³ receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization.

Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP.

Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses.

Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-Î³-producing T cells.

Distinct FcÎ³ receptors mediate the effect of serum amyloid p on neutrophil adhesion and fibrocyte differentiation.

The effect of adjuvanting cancer vaccines with herpes simplex virus glycoprotein D on melanoma-driven CD8+ T cell exhaustion.

T cell antigen discovery using soluble vaccinia proteome reveals recognition of antigens with both virion and nonvirion association.

Recombinant human IgA1 and IgA2 autoantibodies to type VII collagen induce subepidermal blistering ex vivo.

Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism.

Therapy of peritoneally disseminated colon cancer by TAP-deficient embryonic stem cell-derived macrophages in allogeneic recipients.

CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120.

Translational medicine in action: anti-CD20 therapy in lymphoma.

Too much of a good thing? Tim-3 and TCR signaling in T cell exhaustion.

Dendritic cells and B cells: unexpected partners in Th2 development.

Year: 2014 Volume: 193 Issue: 3

Year: 2014 Volume: 193 Issue: 2

Year: 2014 Volume: 193 Issue: 1

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hermance, Nicole Van, Trieu-My Polykratis, Apostolos Kim, Chun Chan, Francis K. M. Pasparakis, Manolis Lee, Thomas H. Zelic, Matija Roderick, Justine Kelliher, Michelle A.
Description	Author Affiliation: Polykratis A ( Institute for Genetics, University of Cologne, 50674 Cologne, Germany); Hermance N ( Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605); Zelic M ( Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605); Roderick J ( Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605); Kim C ( Institute for Genetics, University of Cologne, 50674 Cologne, Germany); Van TM ( Institute for Genetics, University of Cologne, 50674 Cologne, Germany); Lee TH ( Genentech, San Francisco, CA 94080); Chan FK ( Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.); Pasparakis M ( Institute for Genetics, University of Cologne, 50674 Cologne, Germany); Kelliher MA ( Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605)
Abstract	The serine/threonine kinase RIPK1 is recruited to TNFR1 to mediate proinflammatory signaling and to regulate TNF-induced cell death. A RIPK1 deficiency results in perinatal lethality, impaired NFκB and MAPK signaling, and sensitivity to TNF-induced apoptosis. Chemical inhibitor and in vitro-reconstitution studies suggested that RIPK1 displays distinct kinase activity-dependent and -independent functions. To determine the contribution of RIPK1 kinase to inflammation in vivo, we generated knock-in mice endogenously expressing catalytically inactive RIPK1 D138N. Unlike Ripk1(-/-) mice, which die shortly after birth, Ripk1(D138N/D138N) mice are viable. Cells expressing RIPK1 D138N are resistant to TNF- and polyinosinic-polycytidylic acid-induced necroptosis in vitro, and Ripk1(D138N/D138N) mice are protected from TNF-induced shock in vivo. Moreover, Ripk1(D138N/D138N) mice fail to control vaccinia virus replication in vivo. This study provides genetic evidence that the kinase activity of RIPK1 is not required for survival but is essential for TNF-, TRIF-, and viral-initiated necroptosis.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1400590
Journal	The Journal of Immunology
Issue Number	4
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-08-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apoptosis Immunology Hypothermia Mortality Necrosis Receptor-interacting Protein Serine-threonine Kinases Genetics Tumor Necrosis Factor-alpha Pharmacology Adaptor Proteins, Vesicular Transport Animals Drug Effects Cells, Cultured Gene Knock-in Techniques Chemically Induced Inflammation Map Kinase Signaling System Macrophages Mice Mice, Inbred C57bl Nf-kappa B Poly I-c Receptors, Tumor Necrosis Factor, Type I Vaccinia Vaccinia Virus Growth & Development Virus Replication Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

RIPK1 kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor

Intermediate Domain of Receptor-interacting Protein Kinase 1 (RIPK1) Determines Switch between Necroptosis and RIPK1 Kinase-dependent Apoptosis

Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells.

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death

The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation.

The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.

Integrin-linked kinase modulates lipopolysaccharide- and Helicobacter pylori-induced nuclear factor κB-activated tumor necrosis factor- production via regulation of p65 serine 536 phosphorylation.

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo.

Similar Documents

RIPK1 kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor

Intermediate Domain of Receptor-interacting Protein Kinase 1 (RIPK1) Determines Switch between Necroptosis and RIPK1 Kinase-dependent Apoptosis

Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells.

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death

The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation.

The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.

Integrin-linked kinase modulates lipopolysaccharide- and Helicobacter pylori-induced nuclear factor κB-activated tumor necrosis factor- production via regulation of p65 serine 536 phosphorylation.

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo.