NDLI: NK cells promote type 1 T cell immunity through modulating the function of dendritic cells during intracellular bacterial infection.

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NK cells promote type 1 T cell immunity through modulating the function of dendritic cells during intracellular bacterial infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fan, Yijun Qiu, Hongyu Yang, Megan Gao, Xiaoling Jiao, Lei Zhao, Lei Wang, Shuhe Joyee, Antony George Yang, Xi
Description	Author Affiliation: Jiao L ( Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3.)
Abstract	Dendritic cells (DC) play a key role in establishing protective adaptive immunity in intracellular bacterial infections, but the cells influencing DC function in vivo remain unclear. In this study, we investigated the role of NK cells in modulating the function of DC using a murine Chlamydia infection model. We found that the NK cell-depleted mice showed exacerbated disease after respiratory tract Chlamydia muridarum infection, which was correlated with altered T cell cytokine profile. Furthermore, DC from C. muridarum-infected NK-depleted mice (NK(-)DC) exhibited a less mature phenotype compared with that of DC from the infected mice without NK depletion (NK(+)DC). NK(-)DC produced significantly lower levels of both IL-12 and IL-10 than those of NK(+)DC. Moreover, NK(-)DC showed reduced ability to direct primary and established Ag-specific Th1 CD4(+) T cell responses in DC-T coculture systems. More importantly, adoptive transfer of NK(-)DC, in contrast to NK(+)DC, failed to induce type 1 protective immunity in recipients after challenge infection. Finally, NK cells showed strong direct enhancing effect on IL-12 production by DC in an NK-DC coculture system, which was partially reduced by blocking NKG2D receptors signaling and virtually abolished by neutralizing IFN-Î³ activity. The data demonstrate a critical role of NK cells in modulating DC function in an intracellular bacterial infection.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	1
Volume Number	187
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2011-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chlamydia Infections Immunology Chlamydia Muridarum Dendritic Cells Microbiology Intracellular Fluid Killer Cells, Natural Th1 Cells Adoptive Transfer Animals Cell Differentiation Cells, Cultured Metabolism Pathology Coculture Techniques Transplantation Interferon-gamma Biosynthesis Interleukin-12 Mice Mice, Inbred Balb C Mice, Inbred C57bl Mice, Transgenic Nk Cell Lectin-like Receptor Subfamily K Antagonists & Inhibitors Signal Transduction Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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