NDLI: Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor.

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Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor.

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Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xu, Xiaoya Han, Mingyong Jiang, Man Zhang, Ying Bi, Yuli
Description	Author Affiliation: Xu X ( Cancer Therapy and Research Center, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China.); Jiang M ( Cancer Therapy and Research Center, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China.); Zhang Y ( Cancer Therapy and Research Center, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China.); Bi Y ( Cancer Therapy and Research Center, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China.); Han M ( Cancer Therapy and Research Center, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China.)
Abstract	Chronic inflammation is one of the main symptoms of cancer cachexia, and cyclooxygenase 2 inhibitors, such as celecoxib, may be beneficial in counteracting the major symptoms of this syndrome. In the current study, celecoxib was orally administered to BALB/c male mice with colon 26 adenocarcinoma. Tumor growth, survival rate, body weight and food intake of the mice with cancer cachexia were recorded during the experiments. The host inflammatory response was assessed by morphological observations and hematoxylin-eosin staining. The serum levels of vascular endothelial growth factor (VEGF), granulocyte-macrophage colony-stimulating factor, interleukin-6 and tumor necrosis factor- in mice with cancer cachexia were measured by ELISA. Celecoxib administration attenuated the decline in body weight and food intake of mice with cancer cachexia, and improved the survival rate of cachectic mice. Erythrocyte counts and hemoglobin concentration significantly increased in cachectic mice receiving celecoxib compared with control cachectic mice. Notably, celecoxib administration significantly reduced the serum level of VEGF in mice with colon 26 adenocarcinoma, and the cachectic events were also relieved by treatment with a VEGF antibody. The cyclooxygenase 2 inhibitor celecoxib produced positive therapeutic effects in mice with cancer cachexia. This function was regulated at least partly by downregulation of serum levels of VEGF.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-01-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Cachexia Etiology Metabolism Cyclooxygenase 2 Inhibitors Pharmacology Neoplasms Complications Pyrazoles Sulfonamides Vascular Endothelial Growth Factor A Anemia Drug Therapy Animals Antibodies, Monoclonal Body Weight Drug Effects Mortality Celecoxib Cell Line, Tumor Cytokines Disease Models, Animal Gene Expression Regulation Inflammation Mediators Mice Pathology Organ Size Antagonists & Inhibitors Genetics Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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