NDLI: Icariside II inhibits cell proliferation and induces cell cycle arrest through the ROS-p38-p53 signaling pathway in A375 human melanoma cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 15

Year: 2016 Volume: 14

Year: 2016 Volume: 13

Year: 2015 Volume: 12

Year: 2015 Volume: 11

Year: 2015 Volume: 11 Issue: 6

Year: 2015 Volume: 11 Issue: 5

Year: 2015 Volume: 11 Issue: 4

Year: 2015 Volume: 11 Issue: 3

Year: 2015 Volume: 11 Issue: 2

Year: 2015 Volume: 11 Issue: 1

Induction of autophagy contributes to cisplatin resistance in human ovarian cancer cells.

Age-related reduction in calbindin-D28K expression in the Sprague-Dawley rat lens.

Inhibition of cell proliferation by mild hyperthermia at 43Ë C with Paris Saponin I in the lung adenocarcinoma cell line PC-9.

Vanishing lung syndrome in one family: five cases with a 20-year follow-up.

Apoptotic induction of lung adenocarcinoma A549 cells infected by recombinant RVG Newcastle disease virus (rL-RVG) in vitro.

Effects of suppressor of cytokine signaling 1 silencing on human melanoma cell proliferation and interferon-Î³ sensitivity.

miR-143 inhibits cell proliferation by targeting autophagy-related 2B in non-small cell lung cancer H1299 cells.

Inhibitory effects of oligochitosan on TNF- , IL-1ß and nitric oxide production in lipopolysaccharide-induced RAW264.7 cells.

Lycopene attenuates inflammation and apoptosis in post-myocardial infarction remodeling by inhibiting the nuclear factor-κB signaling pathway.

Pharmacology and phytochemistry of the Nitraria genus (Review).

Transforming growth factor-ß1-induced epithelial to mesenchymal transition increases mitochondrial content in the A549 non-small cell lung cancer cell line.

Variations of ABCB4 and ABCB11 genes are associated with primary intrahepatic stones.

Effect of microRNA-21 on multidrug resistance reversal in A549/DDP human lung cancer cells.

Protective effects of icariin-mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion-induced acute lung injury.

GnRH analogues may increase endometrial Hoxa10 promoter methylation and affect endometrial receptivity.

Detection of human papillomavirus and expression of osteopontin in cervical cancer specimens.

Function of interleukin-17 and -35 in the blood of patients with hepatitis B-related liver cirrhosis.

microRNA-22 acts as a metastasis suppressor by targeting metadherin in gastric cancer.

In vivo magnetic resonance imaging tracking of transplanted superparamagnetic iron oxide-labeled bone marrow mesenchymal stem cells in rats with myocardial infarction.

Proteasome inhibitor lactacystin enhances cisplatin cytotoxicity by increasing endoplasmic reticulum stress-associated apoptosis in HeLa cells.

microRNA-335 inhibits proliferation, cell-cycle progression, colony formation, and invasion via targeting PAX6 in breast cancer cells.

MicroRNA-210 knockdown contributes to apoptosis caused by oxygen glucose deprivation in PC12 cells.

Induced pluripotent stem cell-based therapies for inherited arrhythmias: opportunities and challenges involved (Review).

Characterization by phenotypic and genotypic methods of metallo-ß-lactamase-producing Pseudomonas aeruginosa isolated from patients with cystic fibrosis.

Silencing ADAM10 inhibits the in vitro and in vivo growth of hepatocellular carcinoma cancer cells.

Identification of anesthetic-induced expression changes using DNA microarray.

Increased peroxisome proliferator-activated receptor Î³ expression levels in visceral adipose tissue, and serum CCL2 and interleukin-6 levels during visceral adipose tissue accumulation.

Screening for serum biomarkers in patients with chronic hepatitis B with hepatitis B surface antigen seroclearance, following pegylated interferon alpha therapy.

Effects of topical chondrocyte-derived extracellular matrix treatment on corneal wound healing, following an alkali burn injury.

Sprouty2 protein is downregulated in human squamous cell carcinoma of the head and neck and suppresses cell proliferation in vitro.

Reprogramming human adipose tissue stem cells using epidermal keratinocyte extracts

Ampelopsin induces apoptosis by regulating multiple c-Myc/S-phase kinase-associated protein 2/F-box and WD repeat-containing protein 7/histone deacetylase 2 pathways in human lung adenocarcinoma cells.

Systematic profiling of mRNA and miRNA expression in the pancreatic islets of spontaneously diabetic Goto-Kakizaki rats.

Icariside II inhibits cell proliferation and induces cell cycle arrest through the ROS-p38-p53 signaling pathway in A375 human melanoma cells.

Effect of vitamin C administration on hydrogen peroxide-induced cytotoxicity in periodontal ligament cells.

Effect of eicosapentaenoic acid on cholesterol gallstone formation in C57BL/6J mice.

Sirtuin 1 activation enhances the PGC-1 /mitochondrial antioxidant system pathway in status epilepticus.

Inhibition of aldose reductase ameliorates diet-induced nonalcoholic steatohepatitis in mice via modulating the phosphorylation of hepatic peroxisome proliferator-activated receptor .

Hypoxia-induced secretion of platelet-derived growth factor-BB by hepatocellular carcinoma cells increases activated hepatic stellate cell proliferation, migration and expression of vascular endothelial growth factor-A.

Total alkaloids of Rubus alceifolius Poir inhibit tumor angiogenesis through suppression of the Notch signaling pathway in a mouse model of hepatocellular carcinoma.

Association between mutations in the gap junction ß4 gene and nonsyndromic hearing loss: genotype-phenotype correlation patterns.

Association between DNA methylation and multidrug resistance in human glioma SHG-44 cells.

Smad7 maintains epithelial phenotype of ovarian cancer stem-like cells and supports tumor colonization by mesenchymal-epithelial transition.

IL-15 is decreased upon CsA and FK506 treatment of acute rejection following heart transplantation in mice

Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil.

PACE4 regulates proliferation, migration and invasion in human breast cancer MDA-MB-231 cells.

Sorbitol dehydrogenase inhibitor protects the liver from ischemia/reperfusion-induced injury via elevated glycolytic flux and enhanced sirtuin 1 activity.

An enzymatically fortified ginseng extract inhibits proliferation and induces apoptosis of KATO3 human gastric cancer cells via modulation of Bax, mTOR, PKB and IκB .

Stable transfection into rat bone marrow mesenchymal stem cells by lentivirus-mediated NT-3.

Let-7b binding site polymorphism in the B-cell lymphoma-extra large 3'UTR is associated with fluorouracil resistance of hepatocellular carcinoma.

Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis.

Evodiamine sensitizes U87 glioblastoma cells to TRAIL via the death receptor pathway.

Paris saponin VII inhibits metastasis by modulating matrix metalloproteinases in colorectal cancer cells.

Identification of dysregulated pathways associated with pancreatic cancer by survival analysis.

Effect of A disintegrin and metalloproteinase 10 gene silencing on the proliferation, invasion and migration of the human tongue squamous cell carcinoma cell line TCA8113.

Cathepsin L is involved in proliferation and invasion of ovarian cancer cells.

Silencing survivin expression inhibits the tumor growth of non-small-cell lung cancer cells in vitro and in vivo.

Protein-protein interaction network and mechanism analysis in ischemic stroke.

Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation.

Expression profiling of choline and ethanolamine kinases in MCF7, HCT116 and HepG2 cells, and the transcriptional regulation by epigenetic modification.

Ardisia crenata extract stimulates melanogenesis in B16F10 melanoma cells through inhibiting ERK1/2 and Akt activation.

Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor.

Pterostilbene attenuates the inflammatory reaction induced by ischemia/reperfusion in rat heart.

Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats.

Anti-metastatic effect of Smilax china L. extract on MDA-MB-231 cells.

Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2 .

Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells.

Comparative transcriptome analysis between metastatic and non-metastatic gastric cancer reveals potential biomarkers.

Ectopic expression of B and T lymphocyte attenuator in gastric cancer: a potential independent prognostic factor in patients with gastric cancer.

Pinacidil protects osteoblastic cells against antimycin A-induced oxidative damage.

Tumor necrosis factor-related apoptosis-inducing ligand induces cytotoxicity specific to osteosarcoma by microRNA response elements.

Effects of cyclooxygenase-2 gene silencing on the biological behavior of SKOV3 ovarian cancer cells.

Cigarette smoke affects dendritic cell maturation in the small airways of patients with chronic obstructive pulmonary disease.

Interference of Notch 2 inhibits the progression of gliomas and induces cell apoptosis by induction of the cell cycle at the G0/G1 phase.

Octreotide attenuates liver fibrosis by inhibiting hepatic heme oxygenase-1 expression.

Oxysophoridine attenuates the injury caused by acute myocardial infarction in rats through anti-oxidative, anti-inflammatory and anti-apoptotic pathways.

Reactive oxygen species-mediated activation of the Src-epidermal growth factor receptor-Akt signaling cascade prevents bortezomib-induced apoptosis in hepatocellular carcinoma cells.

Exosomes from breast cancer cells stimulate proliferation and inhibit apoptosis of CD133+ cancer cells in vitro.

Knockdown of glucose-regulated protein 78/binding immunoglobulin heavy chain protein expression by asymmetric small interfering RNA induces apoptosis in prostate cancer cells and attenuates migratory capability.

Selection of reference genes for normalization of quantitative polymerase chain reaction data in mouse models of heart failure.

Analysis of metabolic characteristics in a rat model of chronic pancreatitis using high-resolution magic-angle spinning nuclear magnetic resonance spectroscopy.

Single sevoflurane exposure increases methyl-CpG island binding protein 2 phosphorylation in the hippocampus of developing mice.

Crude extract of Polygonum cuspidatum stimulates immune responses in normal mice by increasing the percentage of Mac-3-positive cells and enhancing macrophage phagocytic activity and natural killer cell cytotoxicity.

Electroacupuncture inhibits apoptosis of splenic lymphocytes in traumatized rats through modulation of the TNF- /NF-κB signaling pathway.

Inhibition of SATB1 expression in regulatory T cells contributes to hepatitis B virus-related chronic liver inflammation.

Hepatic Nrf2 expression is altered by quercetin supplementation in X-irradiated rats.

Melatonin alleviates myosin light chain kinase expression and activity via the mitogen-activated protein kinase pathway during atherosclerosis in rabbits.

Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro.

Aplasia Ras homolog member I expression induces apoptosis in renal cancer cells via the ß-catenin signaling pathway.

Comparison of biological properties of umbilical cord-derived mesenchymal stem cells from early and late passages: immunomodulatory ability is enhanced in aged cells.

Inhibition of interleukin-1ß-stimulated matrix metalloproteinases via the controlled release of interleukin-1Ra from chitosan microspheres in chondrocytes.

Neuronal calcium signaling pathways are associated with the development of epilepsy.

microRNA-155 promotes the proliferation of prostate cancer cells by targeting annexin 7.

MicroRNA-106a confers cisplatin resistance in non-small cell lung cancer A549 cells by targeting adenosine triphosphatase-binding cassette A1.

Co-expression analysis of differentially expressed genes in hepatitis C virus-induced hepatocellular carcinoma.

MicroRNA expression profiles associated with acquired gefitinib-resistance in human lung adenocarcinoma cells.

Functional expression, characterization and application of the human S100A4 protein.

Quercetin enhances adriamycin cytotoxicity through induction of apoptosis and regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase/c-Jun N-terminal kinase signaling in multidrug-resistant leukemia K562 cells.

Robinetinidol-flavone attenuates cholesterol synthesis in hepatoma cells via inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Silencing insulin-like growth factor-1 receptor expression inhibits gastric cancer cell proliferation and invasion.

Expression analysis of the estrogen receptor target genes in renal cell carcinoma.

Therapeutic effects of micheliolide on a murine model of rheumatoid arthritis.

Effects of grape seed proanthocyanidin extract on renal injury in type 2 diabetic rats.

Hepcidin promotes osteogenic differentiation through the bone morphogenetic protein 2/small mothers against decapentaplegic and mitogen-activated protein kinase/P38 signaling pathways in mesenchymal stem cells.

Low concentrations of trichosanthin induce apoptosis and cell cycle arrest via c-Jun N-terminal protein kinase/mitogen-activated protein kinase activation.

JNK signaling in hepatocarcinoma cells is associated with the side population upon treatment with anticancer drugs.

Resveratrol attenuates intermittent hypoxia-induced insulin resistance in rats: involvement of Sirtuin 1 and the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway.

Inhibitory effects of C-type natriuretic peptide on the differentiation of cardiac fibroblasts, and secretion of monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1.

Knockdown of Merm1/Wbscr22 attenuates sensitivity of H460 non-small cell lung cancer cells to SN-38 and 5-FU without alteration to p53 expression levels.

Self-complementary adeno-associated virus 5-mediated gene transduction of a novel CD40L mutant confers direct antitumor effects in lung carcinoma.

Year: 2014 Volume: 10

Year: 2014 Volume: 9

Year: 2013 Volume: 8

Year: 2013 Volume: 7

Year: 2012 Volume: 6

Year: 2012 Volume: 5

Year: 2011 Volume: 4

Year: 2010 Volume: 3

Year: 2008 Volume: 1

Icariside II inhibits cell proliferation and induces cell cycle arrest through the ROS-p38-p53 signaling pathway in A375 human melanoma cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Xiaomei Liu, Shuyong Xu, Jinhua Li, Gang Wu, Jinfeng Song, Tao
Description	Author Affiliation: Wu J ( Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.); Song T ( Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 25002, P.R. China.); Liu S ( Department of Radiology, Tai'an City Central Hospital, Tai'an, Shandong 271000, P.R. China.); Li X ( Cancer Center, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.); Li G ( Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.); Xu J ( Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, P.R. China.)
Abstract	Icariside II (IS) is a metabolite of icariin, which is derived from Herba Epimedii. In the present study, the antiproliferative effects of IS on A375 human melanoma cells were examined in vitro and a possible mechanism through the ROS-p38-p53 pathway is discussed. A cell WST-8 assay revealed that treatment with IS markedly reduced cell viability from 77 to 21% (25 and 100 µM, respectively), and cell counting demonstrated that IS treatment reduced cell proliferation. IS treatment also induced cell cycle arrest of A375 cells at the G0/G1 and G2/M transitions and inhibited the expression of cell-cycle related proteins, including cyclin E, cyclin-dependent kinase 2 (CDK2), cyclin B1 and phosphorylated cyclin-dependent kinase 1 (P-CDK1). In this study, it was determined that IS inhibits cell proliferation and induces cell cycle arrest through the generation of reactive oxygen species and activation of p38 and p53. These findings were further supported by the evidence that pretreatment with N-acetyl-L-cysteine, SB203580 or pifithrin- significantly blocked IS-induced reduction of cell viability, increase of cell death and cell cycle arrest. In conclusion, IS inhibits cell proliferation and induces cell cycle arrest. Crucially, it was confirmed that these effects were mediated at least in part by activating the ROS-p38-p53 pathway.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-01-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Cell Cycle Checkpoints Drug Effects Flavonoids Pharmacology Melanoma Metabolism Reactive Oxygen Species Signal Transduction Tumor Suppressor Protein P53 P38 Mitogen-activated Protein Kinases Antineoplastic Agents, Phytogenic Cell Line, Tumor Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in