NDLI: Syngeneic tumor cells can induce alloreactive T killer cells: a biological role for transplantation antigens.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schirrmacher, V. Hübsch, D. Garrido, F.
Abstract	A chemically induced sarcoma of BALB/c (H-2d) mice, MCG4, is shown to induce in BALB/c lymphocytes a primary anti-tumor cytolytic T lymphocyte (CTL) reaction in vitro. The anti-tumor CTL showed tumor specificity but reacted also with normal cells expressing distinct H-2 alloantigens. The CTL response could be shown to be induced by and directed against alloantigenic determinants expressed on two different molecules, one H-2Kk-like the other H-2Dk-like. The biological significance of these findings is discussed with regard to (i) possibility of derepression of normally silent H-2 genes in tumor cells and normal cells, (ii) generation of alloreactivity in ontogeny, and (iii) role of alloreactive T cells in eliminating cells expressing wrong gH-2 antigens.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	77
Language	English
Publisher	National Academy of Sciences
Publisher Date	1980-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Histocompatibility Antigens Physiology Killer Cells, Natural Immunology Sarcoma, Experimental Animals Cytotoxicity, Immunologic H-2 Antigens Lymphocyte Culture Test, Mixed Mice Mice, Inbred BALB C Mice, Inbred Strains Chemically Induced Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Syngeneic tumor cells can induce alloreactive T killer cells: a biological role for transplantation antigens.