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Neuronal calcium signaling pathways are associated with the development of epilepsy.

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Neuronal calcium signaling pathways are associated with the development of epilepsy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Zhiliang Ding, Hu Xu, Ruxiang Meng, Fanxin You, Yu Liu, Jianming
Description	Author Affiliation: Meng F ( Department of Neuronal Surgery, The Military General Hospital of Beijing PLA, Beijing 100007, P.R. China.); You Y ( Department of Neuronal Surgery, The Military General Hospital of Beijing PLA, Beijing 100007, P.R. China.); Liu Z ( Department of Neuronal Surgery, The Military General Hospital of Beijing PLA, Beijing 100007, P.R. China.); Liu J ( Department of Neuronal Surgery, The Military General Hospital of Beijing PLA, Beijing 100007, P.R. China.); Ding H ( Department of Neuronal Surgery, The Military General Hospital of Beijing PLA, Beijing 100007, P.R. China.); Xu R ( Department of Neuronal Surgery, The Military General Hospital of Beijing PLA, Beijing 100007, P.R. China.)
Abstract	Epilepsy is the most common serious neurological disorder worldwide, however, the specific causative factors and mechanisms underlying epilepsy remain unclear. The current study aimed to study the potential genes or pathways associated with epilepsy, based on rat miRNA expression profiles. The microarray dataset GSE49850 was downloaded and analyzed with the TimeCourse R software package, which was used to generate comparisons between the control and electrically-stimulated groups. The target genes of differentially expressed miRNAs were queried in the miRWalk database and functional enrichment was conducted using the Database for Annotation, Visualization and Integrated Discovery software tools. The interaction network of the target genes was constructed based on the Biomolecular Interaction Network Database and clustered using ClusterONE. In total, 152 differentially expressed miRNAs were identified, with rno-miR-21-5p being the most significantly differentially expressed. A total of 526 target genes of the differentially expressed miRNAs were obtained. Functional analysis indicated that these genes were predominantly involved in responses to stimuli. The interaction network showed that the GRIN and STX gene family, which are involved in synaptic signal transmission, were significant. In conclusion, the present study identified that the development of epilepsy was closely associated with neuronal calcium signaling pathways.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2014.2756
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-01-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Calcium Signaling Epilepsy Metabolism Neurons Animals Cluster Analysis Computational Biology Disease Models, Animal Genetics Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Micrornas Molecular Sequence Annotation Rna Interference Rna, Messenger Signal Transduction Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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