NDLI: Sirtuin 1 activation enhances the PGC-1 /mitochondrial antioxidant system pathway in status epilepticus.

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Sirtuin 1 activation enhances the PGC-1 /mitochondrial antioxidant system pathway in status epilepticus.

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Sirtuin 1 activation enhances the PGC-1 /mitochondrial antioxidant system pathway in status epilepticus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Wen Wu, Wei Zhao, Xiu-He Chi, Zhao-Fu Wang, Sheng-Jun Bo, Ning Wang, Xian-Jin
Description	Author Affiliation: Wang SJ ( Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.); Zhao XH ( Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.); Chen W ( Department of Neurology, Jinan Central Hospital, Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China.); Bo N ( Clinical Laboratory, People's Hospital of Shenzhen, Guangdong 518020, P.R. China.); Wang XJ ( Department of Neurology, Shandong Ankang Hospital, Jining, Shandong 272051, P.R. China.); Chi ZF ( Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.); Wu W ( Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.)
Abstract	Sirtuin 1 (SIRT1) regulates numerous neuronal processes, including metabolism, antioxidation and aging, through activation of peroxisome proliferator-activated receptor coactivator 1- (PGC-1 ), an upstream regulator of mitochondrial biogenesis and function. However, the role of SIRT1 in the oxidative stress induced by seizures has yet to be elucidated. The present study aimed to investigate whether SIRT1 was involved in the activation of the PGC-1 /mitochondrial antioxidant system following status epilepticus (SE) in rats. The data demonstrated that SIRT1 expression and activity were enhanced in the rat hippocampus following SE. SIRT1 inhibition effectively blocked the SE-associated increase in PGC-1 and mitochondrial antioxidant enzymes, including superoxide dismutase 2 (SOD2) and uncoupling protein 2 (UCP2). Additionally, it was also demonstrated that the activation of SIRT1 enhanced mitochondrial electron transport chain complex I activity and increased ATP content. In conclusion, the present results suggest that SIRT1 activation may alleviate mitochondrial oxidative stress induced by seizures partially via PGC-1 signaling.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-01-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Antioxidants Metabolism Mitochondria Sirtuin 1 Status Epilepticus Transcription Factors Animals Enzyme Activation Hippocampus Neurons Pathology Oxidative Stress Reactive Oxygen Species Superoxide Dismutase Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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