NDLI: Hepatoprotective effect of juglone on dimethylnitrosamine-induced liver fibrosis and its effect on hepatic antioxidant defence and the expression levels of -SMA and collagen III.

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Hepatoprotective effect of juglone on dimethylnitrosamine-induced liver fibrosis and its effect on hepatic antioxidant defence and the expression levels of -SMA and collagen III.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Weng, Min Zhou, De-Jiang Jiang, Ming-De Zheng, Shu-Mei Zeng, Wei-Zheng Mu, Dong He, Sheng Zhang, Yong
Description	Author Affiliation: Zhou DJ ( Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.); Mu D ( Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.); Jiang MD ( Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.); Zheng SM ( Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.); Zhang Y ( Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.); He S ( Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.); Weng M ( Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.); Zeng WZ ( Internal Medicine Department of Digestion, General Hospital of Chengdu Military Region, Chengdu, Sichuan 610083, P.R. China.)
Abstract	The present study aimed to investigate the antifibrotic effects of juglone on dimethylnitrosamine (DMN)induced fibrosis in rats. Juglone, which is a quinone, significantly decreased DMNinduced rat hepatic fibrosis, which was associated with increased superoxide dismutase (SOD) activity, decreased oxidative stress and reduced levels of smooth muscle actin ( SMA) and collagen (Col) III in the liver. Serum levels of alanine aminotransferase, aspartate aminotransferase, hyaluronic acid, laminin, type III precollagen and type IV collagen were significantly reduced by treatment with juglone. Liver fibrosis was induced in male SpragueDawley rats by subcutaneous injections of DMN solution and hepatic fibrosis was assessed using Massons trichome staining. The expression levels of SMA and Col III were determined using immunohistochemical techniques. The activities of SOD and malondialdehyde in liver homogenates were also determined. The results suggested that juglone augmented the antioxidative capability of the liver, possibly by stimulating the activity of SOD, which promoted the inactivation of hepatic stellate cells (HSCs) and decreased the accumulation of extracellular matrix collagen in the liver, thereby alleviating hepatic fibrosis. Silymarin was used as a positive control for liver fibrosis protection. It was hypothesized that juglone alleviates or mitigates oxidative stressmediated hepatic fibrosis by upregulating the expression of peroxisome proliferatoractivated receptor Î³ and inhibiting the activation of HSC.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2015.3992
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-09-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Actins Metabolism Antioxidants Collagen Type Iii Dimethylnitrosamine Toxicity Liver Cirrhosis, Experimental Prevention & Control Naphthoquinones Pharmacology Protective Agents Genetics Animals Hepatic Stellate Cells Cytology Immunohistochemistry Liver Drug Effects Pathology Chemically Induced Malondialdehyde Rats, Sprague-dawley Superoxide Dismutase Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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