NDLI: Collagen and prostaglandin E2 regulate aromatase expression through the PI3K/AKT/IKK and the MAP kinase pathways in adipose stromal cells.

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Vascular endothelial growth factor affects dendritic cell activity in hypertensive disorders of pregnancy.

Dasatinib enhances antitumor activity of paclitaxel in ovarian cancer through Src signaling

Future opportunities in preventing ototoxicity: Caffeic acid phenethyl ester may be a candidate (Review).

Expression and clinical significance of hypoxia-inducible factor 1 , Snail and E-cadherin in human ovarian cancer cell lines.

Inhibition of FHL1 inhibits cigarette smoke extract-induced proliferation in pulmonary arterial smooth muscle cells.

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MicroRNA-141 inhibits migration of gastric cancer by targeting zinc finger E-box-binding homeobox 2.

Integrative meta-analysis of differentially expressed genes in osteoarthritis using microarray technology.

Suppressor of cytokine signaling 1-modulated metalloproteinases and tissue inhibitor of metalloproteinase in pulmonary fibrosis.

Hereditary protein S deficiency leads to ischemic stroke.

Increase in osteoclastogenesis in an obese Otsuka Long-Evans Tokushima fatty rat model.

Identification of genes associated with laryngeal squamous cell carcinoma samples based on bioinformatic analysis.

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Docosahexaenoic acid inhibits the growth of hormone-dependent prostate cancer cells by promoting the degradation of the androgen receptor.

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Role of hypoxia-inducible factor-1 and CD146 in epidermal growth factor receptor-mediated angiogenesis in salivary gland adenoid cystic carcinoma.

Let-7i inhibits the malignant phenotype of osteosarcoma cells by targeting Aurora-B.

Epigenetic alterations in gastric cancer (Review).

Synuclein-Î³ promotes migration of MCF7 breast cancer cells by activating extracellular-signal regulated kinase pathway and breaking cell-cell junctions.

MicroRNA-29a inhibits cell migration and invasion via targeting Roundabout homolog 1 in gastric cancer cells.

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Isolation and phenotypic characterization of cancer stem-like side population cells in colon cancer.

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Ginsenoside Rg3 induces apoptosis in human multiple myeloma cells via the activation of Bcl-2-associated X protein.

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Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of rapamycin pathways.

Role of HER-2 activity in the regulation of malignant meningioma cell proliferation and motility.

Dermatological disorders in Tuvalu between 2009 and 2012.

Heparin inhibits lipopolysaccharide-induced inflammation via inducing caveolin-1 and activating the p38/mitogen-activated protein kinase pathway in murine peritoneal macrophages.

Myeloid-derived suppressor cells suppress CD4â º and CD8â º T cell responses in autoimmune hepatitis.

Molecular and cellular mechanisms of tight junction dysfunction in the irritable bowel syndrome.

Hepatitis B virus upregulates the expression of kinesin family member 4A.

Interleukin-10 gene transfer into insulin-producing ß cells protects against diabetes in non-obese diabetic mice.

Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels.

MicroRNA-148a inhibits the proliferation and promotes the paclitaxel-induced apoptosis of ovarian cancer cells by targeting PDIA3.

Doxycycline inhibits leukemic cell migration via inhibition of matrix metalloproteinases and phosphorylation of focal adhesion kinase.

MicroRNA-148a inhibits migration and invasion of ovarian cancer cells via targeting sphingosine-1-phosphate receptor 1.

Vaccination with ubiquitin-hepatitis B core antigen-cytoplasmic transduction peptide enhances the hepatitis B virus-specific cytotoxic T-lymphocyte immune response and inhibits hepatitis B virus replication in transgenic mice.

Mutation analysis of two families with inherited congenital cataracts.

Borna disease virus infection impacts microRNAs associated with nervous system development, cell differentiation, proliferation and apoptosis in the hippocampi of neonatal rats.

Identification of a microRNA signature in endothelial cells with mechanical stretch stimulation.

MicroRNA-338-3p suppresses tumor growth of esophageal squamous cell carcinoma in vitro and in vivo.

Inhibition of SHP-2 promotes radiosensitivity in glioma.

Pro-apoptotic and anti-proliferative effects of 3,3'-diindolylmethane in nasopharyngeal carcinoma cells via downregulation of telomerase activity.

Loquat (Eriobotrya japonica) extract prevents dexamethasone-induced muscle atrophy by inhibiting the muscle degradation pathway in Sprague Dawley rats.

Dextromethorphan provides neuroprotection via anti-inflammatory and anti-excitotoxicity effects in the cortex following traumatic brain injury.

Drug exposure in a metastatic human lung adenocarcinoma cell line gives rise to cells with differing adhesion, proliferation, and gene expression: Implications for cancer chemotherapy.

Mass spectrometric identification, characterization and validation of the haptoglobin ß-chain protein as a lung cancer serum biomarker.

Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation

Overexpression of caudal-related homeobox transcription factor 2 inhibits the growth of transplanted colorectal tumors in nude mice.

Gender-specific association between the cytoplasmic poly(A) binding protein 4 rs4660293 single nucleotide polymorphism and serum lipid levels.

Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines.

Positive shift of Nav1.8 current inactivation curve in injured neurons causes neuropathic pain following chronic constriction injury.

Beneficial effects of the traditional medicine Igongsan and its constituent ergosterol on dextran sulfate sodium-induced colitis in mice.

Rg1 exhibits neuroprotective effects by inhibiting the endoplasmic reticulum stress-mediated c-Jun N-terminal protein kinase apoptotic pathway in a rat model of Alzheimer's disease.

Isolation, in vitro culture and identification of a new type of mesenchymal stem cell derived from fetal bovine lung tissues.

Macrocalyxin A inhibits proliferation and induces apoptosis of t (8;21) leukemia cells through mitochondrial signaling pathways and regulates AML-ETO mRNA expression.

Efficacy of coenzyme Q10 in mitigating spinal cord injury-induced osteoporosis.

Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway.

Obesity-associated microRNA-26b regulates the proliferation of human preadipocytes via arrest of the G1/S transition.

Podocalyxin promotes cisplatin chemoresistance in osteosarcoma cells through phosphatidylinositide 3-kinase signaling.

Paxilitaxel induces apoptosis accompanied by protective autophagy in osteosarcoma cells through hypoxia-inducible factor-1 pathway.

Lycium ruthenicum extract alleviates high-fat diet-induced nonalcoholic fatty liver disease via enhancing the AMPK signaling pathway.

Identification of proteins interacting with protein kinase C-Î´ in hyperthermia-induced apoptosis and thermotolerance of Tca8113 cells.

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LW6, a hypoxia-inducible factor 1 inhibitor, selectively induces apoptosis in hypoxic cells through depolarization of mitochondria in A549 human lung cancer cells.

Inhibition of liver fibrosis using vitamin A-coupled liposomes to deliver matrix metalloproteinase-2 siRNA in vitro.

HasmiR125a and 125b are induced by treatment with cisplatin in nasopharyngeal carcinoma and inhibit apoptosis in a p53dependent manner by targeting p53 mRNA.

Prevalence and spectrum of LRRC10 mutations associated with idiopathic dilated cardiomyopathy.

Oxidized-low density lipoprotein accumulates cholesterol esters via the PKC -adipophilin-ACAT1 pathway in RAW264.7 cells.

FHL1 inhibits the growth of tongue squamous cell carcinoma cells via G1/S cell cycle arrest.

Hypoxia enhances cholangiocarcinoma invasion through activation of hepatocyte growth factor receptor and the extracellular signal-regulated kinase signaling pathway

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Apelin/APJ signaling promotes hypoxia-induced proliferation of endothelial progenitor cells via phosphoinositide-3 kinase/Akt signaling.

Expression and purification of the mGITR-Fc fusion protein and its effect on CD4â º T cells and dendritic cells in vitro.

Twist promotes invasion and cisplatin resistance in pancreatic cancer cells through growth differentiation factor 15.

Intrahepatic transplantation of adipose-derived stem cells attenuates the progression of non-alcoholic fatty liver disease in rats.

Cyclin-dependent kinase 5 regulates the proliferation, motility and invasiveness of lung cancer cells through its effects on cytoskeletal remodeling.

Effects of small interfering RNA-mediated downregulation of the Krüppel-like factor 4 gene on collagen metabolism in human hepatic stellate cells.

Angiotensin II type 1 receptor-associated protein plays a role in regulating the local renin-angiotensin system in HSC-T6 cells.

Activation of autophagy in rat brain cells following focal cerebral ischemia reperfusion through enhanced expression of Atg1/pULK and LC3.

Splicing factor 2/alternative splicing factor contributes to extracellular signalregulated kinase activation in hepatocellular carcinoma cells.

Rescue effect of lipid emulsion on bupivacaine-induced cardiac toxicity in cardiomyocytes.

Endogenous hydrogen sulfide is associated with angiotensin II type 1 receptor in a rat model of carbon tetrachloride-induced hepatic fibrosis

Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro.

Effects of oestrogen deficiency on the alveolar bone of rats with experimental periodontitis.

GSK1904529A, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration.

Paeoniflorin ameliorates acute myocardial infarction of rats by inhibiting inflammation and inducible nitric oxide synthase signaling pathways.

CSN5 silencing reverses sorafenib resistance of human hepatocellular carcinoma HepG2 cells.

Determination of whether screening tests for chronic atrophic gastritis really has a positive predictive value.

Toll-like receptor 7/8 agonist, R848, exhibits antitumoral effects in a breast cancer model.

Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells.

Adrenomedullin improves intestinal epithelial barrier function by downregulating myosin light chain phosphorylation in ulcerative colitis rats.

Overexpression of miR199b5p inhibits Ewing's sarcoma cell lines by targeting CCNL1.

Protection of photoreceptors by intravitreal injection of the Y-27632 Rho-associated protein kinase inhibitor in Royal College of Surgeons rats.

MicroRNA-522 reverses drug resistance of doxorubicin-induced HT29 colon cancer cell by targeting ABCB5.

Effects of estrogen deficiency on microstructural changes in rat alveolar bone proper and periodontal ligament.

Effects of astaxanthin on dinitrofluorobenzene-induced contact dermatitis in mice.

Reduced expression of HSP27 following HAD-B treatment is associated with Her2 downregulation in NIH:OVCAR-3 human ovarian cancer cells.

Anti-inflammatory effects of Gualou Guizhi decoction in transient focal cerebral ischemic brains. [Corrected].

Resveratrol amplifies BMP-4-stimulated osteoprotegerin synthesis via p38 MAP kinase in osteoblasts.

Toxicity of nickel ions and comprehensive analysis of nickel ion-associated gene expression profiles in THP-1 cells.

Profiling circulating microRNAs in maternal serum and plasma.

Downregulation of microRNA-210 inhibits osteosarcoma growth in vitro and in vivo.

Functional characterization of the nitrogen permease regulator-like-2 candidate tumor suppressor gene in colorectal cancer cell lines.

Effect of SCH442416 on glutamate uptake in retinal Müller cells at increased hydrostatic pressure.

Protective effects of allicin against ischemic stroke in a rat model of middle cerebral artery occlusion.

Protective effects of ginsenoside Rg1 on aging Sca-1â º hematopoietic cells.

NADPH oxidase-derived production of reactive oxygen species is involved in learning and memory impairments in 16-month-old female rats.

Adipose-derived stem cells improve the viability of nucleus pulposus cells in degenerated intervertebral discs.

Study of the association of the T869C polymorphism of the transforming growth factor-ß1 gene with polycystic ovary syndrome.

Downregulation of Meg3 enhances cisplatin resistance of lung cancer cells through activation of the WNT/ß-catenin signaling pathway.

Wake-promoting actions of median nerve stimulation in TBI-induced coma: An investigation of orexin-A and orexin receptor 1 in the hypothalamic region.

Adiponectin affects vascular smooth muscle cell proliferation and apoptosis through modulation of the mitofusin-2-mediated Ras-Raf-Erk1/2 signaling pathway.

Clinical investigation of TROP-2 as an independent biomarker and potential therapeutic target in colon cancer.

Collagen and prostaglandin E2 regulate aromatase expression through the PI3K/AKT/IKK and the MAP kinase pathways in adipose stromal cells.

Involvement of glutathione and glutathione metabolizing enzymes in human colorectal cancer cell lines and tissues.

Screening of targeted genes in extrahepatic bile ducts of mice with experimental biliary atresia.

Recombinant LH supplementation during IVF cycles with a GnRH-antagonist in estimated poor responders: A cross-matched pilot investigation of the optimal daily dose and timing.

IRX2-mediated upregulation of MMP-9 and VEGF in a PI3K/AKT-dependent manner.

Expression of HAX-1 in colorectal cancer and its role in cancer cell growth.

Protective effect of vitamin E on methyl methanesulfonate-induced teratozoospermia in adult Sprague-Dawley rats.

Purine analogue ENERGI-F706 induces apoptosis of 786-O renal carcinoma cells via 5'-adenosine monophosphate-activated protein kinase activation.

Genomic expression profiling and bioinformatics analysis of pancreatic cancer.

Cadmium-induced autophagy is mediated by oxidative signaling in PC-12 cells and is associated with cytoprotection.

Overexpression of Î´-catenin is associated with a malignant phenotype and poor prognosis in colorectal cancer.

Analysis of polyunsaturated fatty acids and the omega-6 inflammatory pathway in hepatic ischemia/re-perfusion injury.

Nanoparticle-mediated RNA interference of angiotensinogen decreases blood pressure and improves myocardial remodeling in spontaneously hypertensive rats.

Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma.

Blockade of vascular endothelial growth factor-A/receptor 2 exhibits a protective effect on angiotensin-II stimulated podocytes.

Anti-tumor peptide AP25 decreases cyclin D1 expression and inhibits MGC-803 proliferation via phospho-extracellular signal-regulated kinase-, Src-, c-Jun N-terminal kinase- and phosphoinositide 3-kinase-associated pathways.

microRNA-513c suppresses the proliferation of human glioblastoma cells by repressing low-density lipoprotein receptor-related protein 6.

Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge.

Tanshinone IIA exerts antitumor activity against vestibular schwannoma cells by inhibiting the expression of hypoxia-inducible factor-1 .

Liraglutide protects pancreatic ß-cells against free fatty acids in vitro and affects glucolipid metabolism in apolipoprotein E-/- mice by activating autophagy.

Antiproliferative effect of dexamethasone in the MCF-7 breast cancer cell line.

Microarray and ChIP-seq data analysis revealed changes in p53-mediated transcriptional regulation in Nutlin-3-treated U2OS cells.

Engineering and characterization of a symbiotic selection-marker-free vector-host system for therapeutic plasmid production.

MicroRNA-802 suppresses breast cancer proliferation through downregulation of FoxM1.

Mycophenolate mofetil ameliorates diabetic nephropathy through epithelial mesenchymal transition in rats.

Abnormal Wnt signaling and overexpression of ABCG2 contributes to drug efflux properties of side population cells in nasopharyngeal carcinoma.

Downregulation of the expression of HDGF attenuates malignant biological behaviors of hilar cholangiocarcinoma cells.

Neutrophil elastase and its therapeutic effect on leukemia cells.

Quantitative analysis and anti-inflammatory effects of Gleditsia sinensis thorns in RAW 264.7 macrophages and HaCaT keratinocytes.

Emodin inhibits the proliferation of PC3 prostate cancer cells in vitro via the Notch signaling pathway.

DJ-1 upregulates anti-oxidant enzymes and attenuates hypoxia/re-oxygenation-induced oxidative stress by activation of the nuclear factor erythroid 2-like 2 signaling pathway.

CD14 knockdown reduces lipopolysaccharide-induced cell viability and expression of inflammation-associated genes in gastric cancer cells in vitro and in nude mouse xenografts.

MicroRNA-144 acts as a tumor suppressor by targeting Rho-associated coiled-coil containing protein kinase 1 in osteosarcoma cells.

Urinary N telopeptide levels in predicting the anti-nociceptive responses of zoledronic acid and paclitaxel in a rat model of bone metastases.

Rhein inhibits lipopolysaccharide-induced intestinal injury during sepsis by blocking the toll-like receptor 4 nuclear factor-κB pathway.

Ionizing radiation-induced microRNA expression changes in cultured RGC-5 cells.

Quantitative analysis of the mRNA expression levels of BCL2 and BAX genes in human osteoarthritis and normal articular cartilage: An investigation into their differential expression.

Berberine induces apoptosis by suppressing the arachidonic acid metabolic pathway in hepatocellular carcinoma.

Lumican overexpression exacerbates lipopolysaccharide-induced renal injury in mice.

Characteristics of regulatory B10 cells in patients with rheumatoid arthritis with different disease status.

Diagnostic and therapeutic research on ultrasound microbubble/nanobubble contrast agents (Review).

Synergistic effect of HMGB1 knockdown and cordycepin in the K562 human chronic myeloid leukemia cell line.

Estradiol suppresses neuronal firing activity and c-Fos expression in the lateral habenula.

Osthole suppresses the proliferation and accelerates the apoptosis of human glioma cells via the upregulation of microRNA-16 and downregulation of MMP-9.

Assessment of endogenous reference gene suitability for serum exosomal microRNA expression analysis in liver carcinoma resection studies.

High-density lipoprotein synthesis and metabolism (Review).

Knockdown of PKM2 induces apoptosis and autophagy in human A549 alveolar adenocarcinoma cells.

15-hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes.

Triptolide suppresses proliferation, hypoxia-inducible factor-1 and c-Myc expression in pancreatic cancer cells.

Conformational changes in inter- -trypsin inhibitor heavy chain 4 activate its tumor-specific activity in mice with B16 melanoma.

Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion.

Synergistic apoptosis-inducing effect of aspirin and isosorbide mononitrate on human colon cancer cells.

Vorinostat protects against calcium oxalate-induced kidney injury in mice.

Lipoteichoic acid upregulates NF-κB and proinflammatory cytokines by modulating ß-catenin in bronchial epithelial cells.

Expression of podoplanin and vimentin is correlated with prognosis in esophageal squamous cell carcinoma.

Dopamine receptor antagonist thioridazine inhibits tumor growth in a murine breast cancer model.

A single nucleotide polymorphism in primary-microRNA-146a reduces the expression of mature microRNA-146a in patients with Alzheimer's disease and is associated with the pathogenesis of Alzheimer's disease.

Soy isoflavones protect against H2O2-induced injury in human umbilical vein endothelial cells.

Protective effects of tanshinone â ¡A on endothelial progenitor cells injured by tumor necrosis factor- .

Chitosan as an adjuvant for a Helicobacter pylori therapeutic vaccine.

Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma.

Structure and function of Gab2 and its role in cancer (Review)

Coagulation defects associated with massive blood transfusion: A large multicenter study.

Targeted sequencing of cancer-associated genes in hepatocellular carcinoma using next generation sequencing.

Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats.

Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.

Myosin light chain kinase inhibitor ML7 improves vascular endothelial dysfunction via tight junction regulation in a rabbit model of atherosclerosis.

Role of bone morphogenetic protein-2 in osteogenic differentiation of mesenchymal stem cells.

HER 2/neu protein expression in gastric cancer is associated with poor survival.

Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis.

Alendronate, a double-edged sword acting in the mevalonate pathway.

Gene expression profiling analysis of osteosarcoma cell lines.

Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression-associated congenital dysplasia of the temporomandibular joint in mice.

Integrated analysis of gene expression and DNA methylation changes induced by hepatocyte growth factor in human hepatocytes.

Osteopontin induces vascular endothelial growth factor expression in articular cartilage through PI3K/AKT and ERK1/2 signaling.

Brachyury: A sensitive marker, but not a prognostic factor, for skull base chordomas.

Correlation between thyroglobulin gene polymorphisms and autoimmune thyroid disease.

Activation of the endoplasmic reticulum stress pathway involving CHOP in the lungs of rats with hyperoxiainduced bronchopulmonary dysplasia.

Investigation of the structure of anti-human seminal plasma protein single-chain antibody and its association with linker peptide length.

Effects of salinomycin and CGP37157 on head and neck squamous cell carcinoma cell lines in vitro.

Corosolic acid enhances 5-fluorouracil-induced apoptosis against SNU-620 human gastric carcinoma cells by inhibition of mammalian target of rapamycin.

Curcumin inhibits human cytomegalovirus by downregulating heat shock protein 90.

Novel real-time cell analysis platform for the dynamic monitoring of ionizing radiation effects on human tumor cell lines and primary fibroblasts.

Protective effect of pyrroloquinoline quinine on ultraviolet A irradiation-induced human dermal fibroblast senescence in vitro proceeds via the anti-apoptotic sirtuin 1/nuclear factor-derived erythroid 2-related factor 2/heme oxygenase 1 pathway.

Protection of rat intestinal epithelial cells from ischemia/reperfusion injury by (D-Ala2, D-Leu5)-enkephalin through inhibition of the MKK7-JNK signaling pathway.

Hepatoprotective effect of juglone on dimethylnitrosamine-induced liver fibrosis and its effect on hepatic antioxidant defence and the expression levels of -SMA and collagen III.

Chitosan prevents adhesion during rabbit flexor tendon repair via the sirtuin 1 signaling pathway.

Effects of GnRH agonists on the expression of developmental follicular anti-mullerian hormone in varying follicular stages in cyclic mice in vivo.

Arginase inhibition protects against hypoxiainduced pulmonary arterial hypertension.

Zoledronic acid inhibits the pentose phosphate pathway through attenuating the Ras-TAp73-G6PD axis in bladder cancer cells.

Naringin promotes differentiation of bone marrow stem cells into osteoblasts by upregulating the expression levels of microRNA-20a and downregulating the expression levels of PPARÎ³.

LHX6 inhibits breast cancer cell proliferation and invasion via repression of the Wnt/ß-catenin signaling pathway.

MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells.

Characteristics of human umbilical cord mesenchymal stem cells during ex vivo expansion.

Expression of brainspecific angiogenesis inhibitor1 and association with p53, microvessel density and vascular endothelial growth factor in the tissue of human bladder transitional cell carcinoma.

Genetic variation in the coagulation factor V gene and risk of femoral head osteonecrosis.

Targeted knockout of TNF- by injection of lentivirus-mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats.

A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review.

Diterpenoid B derived from Plectranthus excisus inhibits the melanoma cell cycle in the B16 melanoma cell line.

Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer.

Comparative study of IDH1 mutations in gliomas by high resolution melting analysis, immunohistochemistry and direct DNA sequencing.

Lentivirus transduced interleukin-1 receptor antagonist gene expression in murine bone marrow-derived mesenchymal stem cells in vitro.

Association study of C936T polymorphism of the VEGF gene and the C242T polymorphism of the p22phox gene with diabetes mellitus type 2 and distal diabetic polyneuropathy.

Effects of fucoidan on insulin stimulation and pancreatic protection via the cAMP signaling pathway in vivo and in vitro.

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Collagen and prostaglandin E2 regulate aromatase expression through the PI3K/AKT/IKK and the MAP kinase pathways in adipose stromal cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tan, Ting Wang, Lie Wang, Bing
Description	Author Affiliation: Tan T ( Department of Breast Surgery, Fuzhou General Hospital of Nanjing Military Region, Fuzhou, Fujian 350025, P.R. China.); Wang L ( Department of General Surgery, Fuzhou General Hospital of Nanjing Military Region, Fuzhou, Fujian 350025, P.R. China.); Wang B ( Department of General Surgery, Fuzhou General Hospital of Nanjing Military Region, Fuzhou, Fujian 350025, P.R. China.)
Abstract	Excessive local estrogen production in the breast promotes estrogen-dependent breast cancer. Aromatase is a key enzyme in estrogen biosynthesis. Aromatase inhibitors used in the treatment of breast cancer are very effective, but indiscriminately reduce estrogen synthesis in all tissues, causing major sideeffects. It is thus desirable to develop inhibitors that selectively block aromatase and estrogen production in breast cancer. To this end, it is important to identify the mechanisms by which aromatase is activated in the tumor microenvironment. Prostaglandin E2 (PGE2) and collagen are two important factors in the tumor microenvironment, which contribute to tumor development and progression. In this study, we show that collageninduced aromatase expression in adipose stromal cells (ASCs) was significantly reduced by inhibitors of phosphatidylinositide 3kinase (PI3K), IκB kinase (IKK), mitogenactivated protein kinase kinase (MEK), cJun NH2terminal kinase (JNK), protein kinase A (PKA), and by the knockdown of the JunB and AKT2 genes. In addition, PGE2induced aromatase expression was significantly inhibited by inhibitors of IKK, MEK, JNK, p38 and PKA. These results indicate that the PI3K/AKT/IKK and the mitogenactivated protein (MAP) kinase pathways are involved in collagen and PGE2induced aromatase expression, and also suggest that collagen and PGE2induced signaling pathways may crosstalk in regulating aromatase expression. This study enhances our understanding on the mechanism of regulation of aromatase expression by collagen and PGE2. Furthermore, this study provides a theoretical foundation for the development of specific inhibitors of aromatase by exploiting the signaling pathways identified herein in the context of breast cancer.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-09-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Aromatase Metabolism Dinoprostone Physiology Map Kinase Signaling System Stromal Cells Enzymology Adipose Tissue, White Pathology Genetics Breast Neoplasms Drug Therapy Cells, Cultured Enzyme Induction I-kappa B Kinase Isoquinolines Pharmacology Molecular Targeted Therapy Phosphatidylinositol 3-kinases Proto-oncogene Proteins C-akt Sulfonamides Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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