NDLI: Effect of SCH442416 on glutamate uptake in retinal Müller cells at increased hydrostatic pressure.

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Effect of SCH442416 on glutamate uptake in retinal Müller cells at increased hydrostatic pressure.

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Effect of SCH442416 on glutamate uptake in retinal Müller cells at increased hydrostatic pressure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Yong Huang, Shouyue Huang, Ping Zhong, Yisheng Liu, Xiaohong
Description	Author Affiliation: Li Y ( Department of Ophthalmology, Tongren Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200336, P.R. China.); Liu X ( Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, P.R. China.); Huang S ( Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, P.R. China.); Huang P ( Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, P.R. China.); Zhong Y ( Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, P.R. China.)
Abstract	The A2A receptor (A2AR) antagonist has been considered as an attractive option to improve the treatment of neurological disorders, and the function of A2AR antagonist may inhibit the release of glutamate and prevent neuron damage. The aim of the present study was to investigate whether SCH442416 can modulate the glutamate uptake in retinal Müller cells under increased hydrostatic pressure. The levels of glutamine synthetase (GS) and glutamate aspartate transporter (GLAST) were assessed in retinal Müller cells under 40 mmHg pressure for 24 h using reverse transcriptionquantitative polymerase chain reaction and western blotting, and a glutamate uptake assay was performed using a scintillation counting method. Following treatment of the Müller cells with 100 nM SCH442416 under 40 mmHg pressure for 24 h, the mRNA and protein expression levels of GS and GLAST, and glutamate uptake activity were investigated. Under 40 mmHg pressure, the expression levels of GS and GLAST in the Müller cells, and glutamate uptake activity were significantly reduced. Treatment with SCH442416 significantly ameliorated the decreased expression levels of GS and GLAST, and improved the glutamate uptake activity in the retinal Müller cells exposed to 40 mmHg pressure, resulting in increased expression levels of GS and GLAST, and increased glutamate uptake activity in the Müller cells under pressure. These results suggested that SCH442416 may be a potential candidate as a beneficial neuroprotective agent for the treatment of glaucoma by accelerating the clearance of extracellular glutamate.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-09-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Ependymoglial Cells Drug Effects Glutamic Acid Metabolism Pyrazoles Pharmacology Pyrimidines Amino Acid Transport System X-ag Genetics Animals Down-regulation Cytology Glutamate-ammonia Ligase Hydrostatic Pressure Rna, Messenger Rats, Sprague-dawley Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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