NDLI: Differences in gene expression between strabismic and normal human extraocular muscles.

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2013 Volume: 54

Year: 2012 Volume: 53

Year: 2012 Volume: 53 Issue: 13

Year: 2012 Volume: 53 Issue: 12

Year: 2012 Volume: 53 Issue: 11

Year: 2012 Volume: 53 Issue: 10

Year: 2012 Volume: 53 Issue: 9

Morphometric analysis of aqueous humor outflow structures with spectral-domain optical coherence tomography.

Use of the Argus II retinal prosthesis to improve visual guidance of fine hand movements.

Toxicity evaluation of antiglaucoma drugs using stratified human cultivated corneal epithelial sheets.

Regional variations in mechanical strain in the posterior human sclera.

FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF.

Association between ocular dominance and spherical/astigmatic anisometropia, age, and sex: analysis of 1274 hyperopic individuals.

Relationship between clinical macular changes and retinal function in age-related macular degeneration.

Changes in optic nerve head circulation in response to vasoactive agents: intereye comparison in monkeys with experimental unilateral glaucoma.

Transscleral optical spectroscopy of uveal melanoma in enucleated human eyes.

Transforming growth factor-ß2 induces synthesis and secretion of endothelin-1 in human trabecular meshwork cells.

Ocular anterior segment dysgenesis upon ablation of p120 catenin in neural crest cells.

Biofilm-forming capacity of Staphylococcus epidermidis, Staphylococcus aureus, and Pseudomonas aeruginosa from ocular infections.

Mesenchymal stem cells in the human corneal limbal stroma.

Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.

Development of retinal pigment epithelium from human parthenogenetic embryonic stem cells and microRNA signature.

Association of conjunctival bacterial infection and female sex in cicatricial trachoma.

Effect of image compression and resolution on retinal vascular caliber.

Abnormal retinal vascular reactivity in individuals with impaired glucose tolerance: a preliminary study.

Different subsets of tumor-infiltrating lymphocytes correlate with macrophage influx and monosomy 3 in uveal melanoma.

Validation of point-wise exponential regression to measure the decay rates of glaucomatous visual fields.

Flash responses of mouse rod photoreceptors in the isolated retina and corneal electroretinogram: comparison of gain and kinetics.

Visual characteristics of elderly night drivers in the Salisbury Eye Evaluation Driving Study.

Myopia progression in children is linked with reduced foveal mfERG response.

Intravitreal silicon-based quantum dots as neuroprotective factors in a model of retinal photoreceptor degeneration.

Retinal vessel oxygen saturation in healthy individuals.

Fundus autofluorescence findings in a mouse model of retinal detachment.

Antibody-mediated retinal pericyte injury: implications for diabetic retinopathy.

Differences in gene expression between strabismic and normal human extraocular muscles.

Differential effects of trabecular meshwork stiffness on outflow facility in normal human and porcine eyes.

Induction of autophagy and cell death by tamoxifen in cultured retinal pigment epithelial and photoreceptor cells.

Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland.

Unoprostone isopropyl and metabolite M1 activate BK channels and prevent ET-1-induced [Ca²â º]i increases in human trabecular meshwork and smooth muscle.

In vitro effects of three blood derivatives on human corneal epithelial cells.

Effect of contrast, stimulus density, and viewing distance on multifocal steady-state visual evoked potentials (MSVs).

A novel technique of adjusting segmentation boundary layers to achieve comparability of retinal thickness and volumes between spectral domain and time domain optical coherence tomography.

Right and left correlation of retinal vessel caliber measurements in anisometropic children: effect of refractive error.

Mitochondrial superoxide anion overproduction in Tet-mev-1 transgenic mice accelerates age-dependent corneal cell dysfunctions.

Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae.

Confocal comparison of corneal nerve regeneration and keratocyte reaction between FS-LASIK, OUP-SBK, and conventional LASIK.

Comparison of two spectral domain optical coherence tomography devices for angle-closure assessment.

Ocular pharmacokinetics of bevacizumab in vitrectomized eyes with silicone oil tamponade.

Changes in lens power in Singapore Chinese children during refractive development.

The use of fluorescent quenching in studying the contribution of evaporation to tear thinning.

A randomized, controlled trial of an intervention promoting cataract surgery acceptance in rural China: the Guangzhou Uptake of Surgery Trial (GUSTO).

Chemokine receptor expression in peripheral blood monocytes from patients with neovascular age-related macular degeneration.

Expression of toll-like receptor 4 contributes to corneal inflammation in experimental dry eye disease.

Moderately reduced ATP levels promote oxidative stress and debilitate autophagic and phagocytic capacities in human RPE cells.

Correlations between tear cytokines, chemokines, and soluble receptors and clinical severity of dry eye disease.

Albino mice as an animal model for infantile nystagmus syndrome.

Immune mediators in vitreous fluids from patients with vitreoretinal B-cell lymphoma.

Eye position stability in amblyopia and in normal binocular vision.

Attenuation of ephrinB2 reverse signaling decreases vascularized area and preretinal vascular tuft formation in the murine model of oxygen-induced retinopathy.

Long-term changes in corneal structure and tear inflammatory mediators after orthokeratology and LASIK.

Laminar displacement and prelaminar tissue thickness change after glaucoma surgery imaged with optical coherence tomography.

Longitudinal changes in retinal nerve fiber layer thickness after vitrectomy for rhegmatogenous retinal detachment.

RPGR-associated retinal degeneration in human X-linked RP and a murine model.

Modeling the effect of forward scatter and aberrations on visual acuity after endothelial keratoplasty.

Exclusion of RPGRIP1 ins44 from primary causal association with early-onset cone-rod dystrophy in dogs.

Chromatic pupillometry dissects function of the three different light-sensitive retinal cell populations in RPE65 deficiency.

Pharmacologic Manipulation of Conventional Outflow Facility in Ex Vivo Mouse Eyes

Suppression of murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related Peptide gene.

Transcorneal electrical stimulation shows neuroprotective effects in retinas of light-exposed rats.

Characterization of pupil responses to blue and red light stimuli in autosomal dominant retinitis pigmentosa due to NR2E3 mutation.

Decreased microRNA-155 expression in ocular Behcet's disease but not in Vogt Koyanagi Harada syndrome.

Genetic, behavioral, and sociodemographic risk factors for second eye progression in age-related macular degeneration.

Screening of ocular enterobacteriaceae isolates for presence of chromosomal blaNDM-1 and ESBL genes: a 2-year study at a tertiary eye care center.

Quantitative morphometry of perifoveal capillary networks in the human retina.

Diagnostic ability of retinal nerve fiber layer thickness measurements and neurologic hemifield test to detect chiasmal compression.

Behavior of SD-OCT-detected hyperreflective foci in the retina of anti-VEGF-treated patients with diabetic macular edema.

Comparative ocular microbial communities in humans with and without blepharitis.

Muscarinic antagonist control of myopia: evidence for M4 and M1 receptor-based pathways in the inhibition of experimentally-induced axial myopia in the tree shrew.

A Perioculomotor Nitridergic Population in the Macaque and Cat

Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy.

Prevalence of myopia and its association with body stature and educational level in 19-year-old male conscripts in seoul, South Korea.

Peripheral vision of youths with low vision: motion perception, crowding, and visual search.

Assessment of vision-related quality of life in dry eye patients.

Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy.

Influence of anterior segment power on the scan path and RNFL thickness using SD-OCT.

Comparison of different methods of glycerol preservation for deep anterior lamellar keratoplasty eligible corneas.

Mesenchymal stem cells derived from human limbal niche cells.

Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography.

Does retinal vascular geometry vary with cardiac cycle?

The association between retinal vessel diameter and retinal nerve fiber layer thickness in asymmetric normal tension glaucoma patients.

Wavelength-dependent change of retinal nerve fiber layer reflectance in glaucomatous retinas.

Effect of vitrectomy on aqueous VEGF concentration and pharmacokinetics of bevacizumab in macaque monkeys.

Quantitative confocal imaging of the retinal microvasculature in the human retina.

In vitro amyloid aggregate forming ability of TGFBI mutants that cause corneal dystrophies.

Expression of angiogenesis-related factors in human corneas after cultivated oral mucosal epithelial transplantation.

Individual differences in binocular coordination are uncovered by directly comparing monocular and binocular reading conditions.

Effect of angle of incidence on macular thickness and volume measurements obtained by spectral-domain optical coherence tomography.

A neurobehavioral analysis of the prevention of visual impairment in the DBA/2J mouse model of glaucoma.

Author response: is drusen area really so important?

Activated blood coagulation factor X (FXa) induces angiogenic growth factor expression in human retinal pigment epithelial cells.

Antifibrotic effects of quercetin in primary orbital fibroblasts and orbital fat tissue cultures of Graves' orbitopathy.

Increased prostaglandin E2 (PGE2) levels in proliferative diabetic retinopathy, and correlation with VEGF and inflammatory cytokines.

Retinal nerve fiber layer thickness reproducibility using seven different OCT instruments.

Genome-wide expression profiling of patients with primary open angle glaucoma.

Moving from PROMs to POEMs for glaucoma care: a qualitative scoping exercise.

Neural and vascular responses to fused binocular stimuli: a VEP and fNIRS study.

Monitoring of cornea elastic properties changes during UV-A/riboflavin-induced corneal collagen cross-linking using supersonic shear wave imaging: a pilot study.

Pretreatment with proteasome inhibitors protects against oxidative injuries via PPAR -dependent and -independent pathways in ARPE-19 cells.

Pupillometry: a clinical measure of retinal function in inherited disease.

Comparative resilience of clinical perimetric tests to induced levels of intraocular straylight.

Toward a better understanding of tear film stability.

Nonspecific PCR amplification of CRYBB2-pseudogene leads to misconception of natural variation as mutation.

Author response: Nintendo Wii remote controllers for head posture measurement--accuracy, validity, and reliability of the infrared optical head tracker letters.

Author response: Analysis of the use of multiple comparison corrections in ophthalmology research.

Year: 2012 Volume: 53 Issue: 8

Year: 2012 Volume: 53 Issue: 7

Year: 2012 Volume: 53 Issue: 6

Year: 2012 Volume: 53 Issue: 5

Year: 2012 Volume: 53 Issue: 4

Year: 2012 Volume: 53 Issue: 3

Year: 2012 Volume: 53 Issue: 2

Year: 2012 Volume: 53 Issue: 1

Year: 2011 Volume: 52

Year: 2010 Volume: 51

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Differences in gene expression between strabismic and normal human extraocular muscles.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Altick, Amy L. Von Bartheld, Christopher S. Feng, Cheng-Yuan Schlauch, Karen Johnson, L. Alan
Description	Country affiliation: United States Author Affiliation: Altick AL ( Department of Physiology & Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA.)
Abstract	PURPOSE: Strabismic extraocular muscles (EOMs) differ from normal EOMs in structural and functional properties, but the gene expression profile of these two types of EOM has not been examined. Differences in gene expression may inform about causes and effects of the strabismic condition in humans. METHODS: EOM samples were obtained during corrective surgery from patients with horizontal strabismus and from deceased organ donors with normal EOMs. Microarrays and quantitative PCR identified significantly up- and down-regulated genes in EOM samples. Analysis was performed on probe sets with more than 3-fold differential expression between normal and strabismic samples, with an adjusted P value of ≤ 0.05. RESULTS: Microarray analysis showed that 604 genes in these samples had significantly different expression. Expression predominantly was upregulated in genes involved in extracellular matrix structure, and down-regulated in genes related to contractility. Expression of genes associated with signaling, calcium handling, mitochondria function and biogenesis, and energy homeostasis also was significantly different between normal and strabismic EOM. Skeletal muscle PCR array identified 22 (25%) of 87 muscle-specific genes that were significantly down-regulated in strabismic EOMs; none was significantly upregulated. CONCLUSIONS: Differences in gene expression between strabismic and normal human EOMs point to a relevant contribution of the peripheral oculomotor system to the strabismic condition. Decreases in expression of contractility genes and increases of extracellular matrix-associated genes indicate imbalances in EOM structure. We conclude that gene regulation of proteins fundamental to contractile mechanics and extracellular matrix structure is involved in pathogenesis and/or consequences of strabismus, suggesting potential novel therapeutic targets.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.12-9785
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	53
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2012-08-03
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Expression Regulation Physiology Oculomotor Muscles Metabolism Strabismus Genetics Adolescent Extracellular Matrix Proteins Oligonucleotide Array Sequence Analysis Rna, Messenger Real-time Polymerase Chain Reaction Research Support, N.i.h., Extramural Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in