NDLI: Relationship between clinical macular changes and retinal function in age-related macular degeneration.

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Relationship between clinical macular changes and retinal function in age-related macular degeneration.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Aung, Khin Zaw Guymer, Robyn H. Busija, Lucy Dimitrov, Peter N. Makeyeva, Galina Vingrys, Algis J. Varsamidis, Mary Robman, Liubov D.
Description	Country affiliation: Australia Author Affiliation: Dimitrov PN ( Center for Eye Research Australia, The University of Melbourne, The Royal Victorian Eye and Ear Hospital, Victoria, Australia. dimitrov@unimelb.edu.au)
Abstract	PURPOSE: The aim of this study was to investigate the relationship between clinical macular changes and retinal function in age-related macular degeneration (AMD). METHODS: We recruited 357 participants with visual acuity of better than 20/60 in the study eye, including 64 individuals with normal fundi and 293 AMD participants classified into 12 subgroups based upon the International Classification and Grading System. Visual function in the study eye was assessed using two steady-state tests (achromatic 14 Hz flicker [F14Hz] and isoluminant blue color [BCT]) and two adaptation measurements (cone photo-stress recovery rate [CRR] and rod dark adaptation recovery rate [RRR]). The groups were compared on their average psychophysical measurements and ranked according to functional deficiency. RESULTS: Both adaptation parameters were significantly abnormal when only hard and/or intermediate drusen were evident (compared to controls, P < 0.023) and yielded considerably worse outcomes in cases with more advanced fundus changes (P < 0.001), but provided limited ability to discriminate between these cases (linear trend, CRR t = 0.68, P = 0.50 and RRR t = 1.76, P = 0.08). Steady-state measurements, however, declined gradually along the entire hierarchy of fundus changes (linear trend, F14Hz t = 10.16, P < 0.001 and BCT t = 11.19, P < 0.001) with F14Hz being able to detect significant functional change as early as in the intermediate drusen group, when compared to controls (P = 0.003). CONCLUSIONS: Steady state thresholds (F14Hz and BCT) and clinical signs showed significant concordance across the spectrum of early AMD fundus changes. This suggests that these tests may be an effective tool for monitoring progression of AMD to supplement clinical grading.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	53
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2012-08-07
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Macula Lutea Physiopathology Macular Degeneration Fundus Oculi Pathology Optic Disk Drusen Photoreceptor Cells, Vertebrate Physiology Pigment Epithelium Of Eye Prognosis Visual Acuity Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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