NDLI: Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.

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Microarray analysis of murine retinal light damage reveals changes in iron regulatory, complement, and antioxidant genes in the neurosensory retina and isolated RPE.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Yafeng Kumar, Usha Hadziahmetovic, Majda Song, Ying Song, Delu Grieco, Steven Tobias, John W. Dunaief, Joshua L.
Description	Country affiliation: United States Author Affiliation: Hadziahmetovic M ( FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.)
Abstract	PURPOSE: The purpose of this study was to investigate light damage-induced transcript changes within neurosensory retina (NSR) and isolated retinal pigment epithelium (RPE). Similar studies have been conducted previously, but were usually limited to the NSR and only a portion of the transcriptome. Herein most of the transcriptome, not just in the NSR but also in isolated RPE, was queried. METHODS: Mice were exposed to 10,000 lux cool white fluorescent light for 18 hours and euthanized 4 hours after photic injury. NSR and isolated RPE were collected, and RNA was isolated. DNA microarray hybridization was conducted as described in the Affymetrix GeneChip Expression Analysis Technical Manual. Microarray analysis was performed using probe intensity data derived from the Mouse Gene 1.0 ST Array. For the genes of interest, confirmation of gene expression was done using quantitative real-time PCR. Immunofluorescence assessed protein levels and localization. RESULTS: Numerous iron regulatory genes were significantly changed in the light-exposed NSR and RPE. Several of these gene expression changes favored an iron-overloaded state. For example, the transferrin receptor was upregulated in both light-exposed NSR and RPE. Consistent with this, there was stronger transferrin receptor immunoreactivity in the light-exposed retinas. Significant changes in gene expression following light damage were also observed in oxidative stress and complement system genes. CONCLUSIONS: The concept of a photooxidative stress-induced vicious cycle of increased iron uptake leading to further oxidative stress was introduced.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.12-10204
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	53
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2012-08-07
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antioxidants Physiology Complement System Proteins Genetics Iron-regulatory Proteins Adverse Effects Retina Metabolism Animals Fluorescent Antibody Technique Gene Expression Homeostasis Radiation Effects In Vitro Techniques Mice Mice, Inbred Balb C Microarray Analysis Oxidative Stress Real-time Polymerase Chain Reaction Retinal Pigment Epithelium Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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