NDLI: Toxicity evaluation of antiglaucoma drugs using stratified human cultivated corneal epithelial sheets.

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Toxicity evaluation of antiglaucoma drugs using stratified human cultivated corneal epithelial sheets.

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Toxicity evaluation of antiglaucoma drugs using stratified human cultivated corneal epithelial sheets.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Araie, Makoto Yokoo, Seiichi Usui, Tomohiko Mori, Yosai Omichi, Sachiko Miyata, Kazunori Nakagawa, Suguru Aihara, Makoto Kimakura, Mikiko Amano, Shiro
Description	Country affiliation: Japan Author Affiliation: Nakagawa S ( Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan.)
Abstract	PURPOSE: To investigate the toxicity profiles of seven antiglaucoma topical eye drops and benzalkonium chloride (BAC) using stratified cultivated human corneal epithelial cell sheets (HCES) in a serum-free culture system. METHODS: A range of prostaglandin analogies and preservatives, including BAC, sofZia (SZ), sodium benzoate (SB), and polyquaternium-1 (PQ) were tested. The barrier function and cell viability were examined by a carboxyfluorescein permeability assay and WST-1 assay. Histological evaluation of the HCES was also performed after application of each solution. RESULTS: The carboxyfluorescein permeability assay had a higher sensitivity for the detection of toxicity of test solutions than the WST-1 assay or histological examination. Latanoprost BAC, latanoprost/timolol BAC, and 0.02% or higher concentration of BAC were the most toxic, followed by latanoprost SB, latanoprost preservative-free, BAC 0.002%, and travoprost/ latanoprost PQ. Travoprost SZ and tafluprost BAC (preserved with 0.001% BAC) was the least toxic in our experimental conditions. CONCLUSIONS: The carboxyfluorescein permeability assay using HCES in a serum-free system was the most useful for the quantification of toxicity of ophthalmic solutions. Among the regimens examined, a BAC concentration of 0.001% or lower or non-BAC preservative sofZia was suggested to be the least toxic to the ocular surface.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	53
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2012-08-03
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antihypertensive Agents Toxicity Epithelium, Corneal Drug Effects Benzalkonium Compounds Cell Membrane Permeability Cell Survival Cells, Cultured Culture Media, Serum-free Drug Combinations Fluoresceins Metabolism Fluorescent Dyes Glaucoma Drug Therapy Membrane Proteins Ophthalmic Solutions Phosphoproteins Preservatives, Pharmaceutical Prostaglandins F, Synthetic Timolol Zonula Occludens-1 Protein Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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