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A neurobehavioral analysis of the prevention of visual impairment in the DBA/2J mouse model of glaucoma.

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A neurobehavioral analysis of the prevention of visual impairment in the DBA/2J mouse model of glaucoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Brown, Richard E. Wong, Aimée A.
Description	Country affiliation: Canada Author Affiliation: Wong AA ( Department of Psychology and Neuroscience Institute, Dalhousie University, Halifax, Nova Scotia, Canada.)
Abstract	PURPOSE: Timoptic-XE treatment was used to examine the relationship between age-related changes in intraocular pressure (IOP), retinal cell loss, visual ability, and neuronal labeling in the superior colliculus in the DBA/2J mouse model of pigmentary glaucoma. METHODS: Mice were administered Timoptic-XE (0.0%, 0.25%, or 0.50%) daily from 9 weeks to 12 months of age. Visual ability and IOP were evaluated at 3, 6, 9, and 12 months of age. Mice from each group were then given intraocular injections of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP), and estimates of the number of cells in the ganglion cell layer of the retina, WGA-HRP transneural labeling of cells, cell count, and cross-sectional area of Nissl-stained cells in the superior colliculus were obtained. RESULTS: Mice treated with 0.50% and 0.25% Timoptic-XE maintained a high level of performance in behavioral vision tasks, while 12-month-old untreated mice (0.0% Timoptic-XE) exhibited impaired visual performance. Timoptic-XE therapy reduced IOP and cell loss in the ganglion cell layer of the retina and prevented somal shrinkage and the decrease in WGA-HRP transneural labeling in the superior colliculus that occurred in untreated mice at 12 months of age. CONCLUSIONS: This study provides a comprehensive assessment of the efficacy of Timoptic-XE in DBA/2J mice by correlating age-related visual system changes in the retina and brain with changes in IOP and visual ability. These results showed that reducing IOP not only rescued retinal ganglion cell atrophy but also restored visual function and altered patterns of neurodegeneration that occur with blindness.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	53
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2012-08-31
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adrenergic Beta-antagonists Administration & Dosage Behavior, Animal Physiology Disease Models, Animal Glaucoma, Open-angle Prevention & Control Timolol Vision Disorders Visual Perception Administration, Topical Aging Animals Cell Count Physiopathology Intraocular Pressure Drug Effects Mice Mice, Inbred Dba Ophthalmic Solutions Retinal Ganglion Cells Pathology Superior Colliculi Wheat Germ Agglutinin-horseradish Peroxidase Conjugate Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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