NDLI: Fundus autofluorescence findings in a mouse model of retinal detachment.

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Fundus autofluorescence findings in a mouse model of retinal detachment.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Staurenghi, Giovanni Sparrow, Janet R. Kong, Jian Blonska, Anna M. Secondi, Roberta
Description	Country affiliation: United States Author Affiliation: Secondi R ( Department of Ophthalmology, Columbia University, New York, New York 10032, USA.)
Abstract	PURPOSE: Fundus autofluorescence (fundus AF) changes were monitored in a mouse model of retinal detachment (RD). METHODS: RD was induced by transscleral injection of hyaluronic acid (Healon) or sterile balanced salt solution (BSS) into the subretinal space of 4-5-day-old albino Abca4 null mutant and Abca4 wild-type mice. Images acquired by confocal scanning laser ophthalmoscopy (Spectralis HRA) were correlated with spectral domain optical coherence tomography (SD-OCT), infrared reflectance (IR), fluorescence spectroscopy, and histologic analysis. Results. In the area of detached retina, multiple hyperreflective spots in IR images corresponded to punctate areas of intense autofluorescence visible in fundus AF mode. The puncta exhibited changes in fluorescence intensity with time. SD-OCT disclosed undulations of the neural retina and hyperreflectivity of the photoreceptor layer that likely corresponded to histologically visible photoreceptor cell rosettes. Fluorescence emission spectra generated using flat-mounted retina, and 488 and 561 nm excitation, were similar to that of RPE lipofuscin. With increased excitation wavelength, the emission maximum shifted towards longer wavelengths, a characteristic typical of fundus autofluorescence. CONCLUSIONS: In detached retinas, hyper-autofluorescent spots appeared to originate from photoreceptor outer segments that were arranged within retinal folds and rosettes. Consistent with this interpretation is the finding that the autofluorescence was spectroscopically similar to the bisretinoids that constitute RPE lipofuscin. Under the conditions of a RD, abnormal autofluorescence may arise from excessive production of bisretinoid by impaired photoreceptor cells.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.12-9672
Journal	Investigative Opthalmology & Visual Science
Issue Number	9
Volume Number	53
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2012-08-07
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Fundus Oculi Retinal Detachment Pathology Animals Disease Models, Animal Fluorescence Mice Photoelectron Spectroscopy Tomography, Optical Coherence Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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