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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Birch, David G. Williams, Patrick D. Callanan, David Wang, Robert Locke, Kirsten G. Hood, Donald C. |
| Description | Country affiliation: United States Author Affiliation: Birch DG ( The Retina Foundation of the Southwest, Dallas, Texas 75231, USA. dbirch@retinafoundation.org) |
| Abstract | PURPOSE: The purpose of this study was to evaluate macular atrophy by frequency-domain optical coherence tomography (OCT) in patients with birdshot retinochoroidopathy and to compare the resulting thickness measures with visual acuity and multifocal electroretinography (mfERG). METHODS: Measures were obtained from 14 eyes of 7 patients with birdshot retinochoroidopathy and 23 normal eyes. Optical coherence tomography-3 measures of macular thinning were related to visual acuity, mfERG response density, and time since diagnosis. Horizontal midline frequency-domain OCT scans identified which layers of the retina were primarily responsible for macular thinning. RESULTS: All eyes with a history of birdshot retinochoroidopathy for >10 years had abnormal mfERG response densities. Compared with those without anatomic thinning (n = 8), eyes with anatomic thinning (n = 6) had significantly lower visual acuity (P = 0.0006), foveal response density (P = 0.006), and overall mfERG response density (P = 0.009). Segmentation of retinal layers on frequency-domain OCT scans showed that anatomic thinning was as a result of reduction in the receptor 1 layer (REC+), the thickness of the segment extending from the proximal border of the outer plexiform layer to the Bruch membrane-choroid interface. CONCLUSION: Macular atrophy, as reflected in OCT evidence of macular thinning and mfERG evidence of macular function, occurs in patients with long-standing birdshot retinochoroidopathy. Measures of retinal layer thicknesses by frequency-domain OCT suggest that the atrophy occurs primarily in the outer retina. |
| File Format | HTM / HTML |
| ISSN | 0275004X |
| e-ISSN | 15392864 |
| DOI | 10.1097/IAE.0b013e3181c720b4 |
| Journal | Retina |
| Issue Number | 6 |
| Volume Number | 30 |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2010-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Ophthalmology Choroid Diseases Physiopathology Electroretinography Macula Lutea Pathology Retinal Diseases Tomography, Optical Coherence Atrophy Choroid Photoreceptor Cells, Vertebrate Retinal Pigment Epithelium Visual Acuity Physiology Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
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