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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Konstas, Anastasios G. P. Quaranta, Luciano Realini, Tony |
| Description | Country affiliation: Greece Author Affiliation: Konstas AG ( 1st University Department of Ophthalmology, AHEPA Hospital, Glaucoma Unit, Thessaloniki, Greece. konstas@med.auth.gr) |
| Abstract | INTRODUCTION: Glaucoma is the second leading cause of blindness globally, representing a significant public health concern. More than 60 million people are affected by glaucoma worldwide; as this population ages, the number is expected to increase. Glaucoma is a collection of heterogeneous diseases sharing common clinical characteristics. The goal of treatment is to prevent significant visual dysfunction through reduction of intraocular pressure (IOP). AREAS COVERED: This is a review of the current literature about combination therapeutic regimens for the reduction of IOP, focusing on the risk : benefit profile of a fixed-combination therapy using travoprost and timolol. EXPERT OPINION: Since the debut of prostaglandin analogues in the 1990s, only modest innovation has occurred in glaucoma pharmacology. A growing body of research has established that the preservative benzalkonium chloride (BAK) might not be the benign contributor expected of excipient ingredients. Thus, BAK-free treatments were developed, with the goal of IOP reduction without furthering ocular surface disease symptoms. The BAK-free travoprost/timolol combination represents an important addition to glaucoma medication options and may fill an unmet need in this therapeutic arena. |
| File Format | HTM / HTML |
| ISSN | 14656566 |
| Issue Number | 5 |
| Volume Number | 13 |
| e-ISSN | 17447666 |
| Journal | Expert Opinion on Pharmacotherapy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antihypertensive Agents Therapeutic Use Cloprostenol Analogs & Derivatives Glaucoma Drug Therapy Timolol Animals Pharmacology Benzalkonium Compounds Drug Combinations Humans Preservatives, Pharmaceutical Travoprost Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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