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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Talib, Abou Nasser Abdelhamid, Hani Wu, Hui-Fen Manikandan, M. |
| Description | Country affiliation: Taiwan Author Affiliation: Manikandan M ( Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, 70, Lien-Hai Road, 80424, Taiwan); Nasser Abdelhamid H ( Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, 70, Lien-Hai Road, 80424, Taiwan); Talib A ( Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University, Kaohsiung, 70, Lien-Hai Road, 80424, Taiwan.); Wu HF ( Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, 70, Lien-Hai Road, 80424, Taiwan) |
| Abstract | Several surface enhanced Raman spectroscopy (SERS) substrates were prepared based on in situ nucleation of gold nanohexagons (Au) on graphene (G) nanosheets (Au@G), G, Au nanoparticles and Au conjugated G nanomaterials. These were applied to enhance Raman scattering and to differentiate human breast normal, cancer and cancer stem cells. These SERS substrates at concentrations of 100 µg/1 × 10(4) cells led to 5.4 fold increase in detecting breast cancer cells (BCCs) and 4.8 fold of sensitivity for detecting breast cancer stem cells (BCSCs) and they were able to identify and differentiate between normal cells, cancer cells and cancer stem cells. These approaches are rapid, simple and reliable for healthy normal cells, cancer cells and cancer stem cell detection which have a huge potential for cancer research for medical or biomedicine applications. |
| ISSN | 09565663 |
| Volume Number | 55 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-05-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Breast Neoplasms Diagnosis Gold Graphite Chemistry Metal Nanoparticles Nanoparticles Neoplastic Stem Cells Pathology Spectrum Analysis, Raman Methods Biosensing Techniques Crystallization Diagnosis, Differential Humans Tumor Cells, Cultured Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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