NDLI: Optical waveguide sensor based on silica nanotube arrays for label-free biosensing.

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Preface. Biosensors 2014.

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Optical waveguide sensor based on silica nanotube arrays for label-free biosensing.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sun, Shuqing Teramae, Norio He, Yonghong Ding, Yu Ma, Hui Fan, Yong
Description	Country affiliation: China Author Affiliation: Fan Y ( Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzen 518055, China); Ding Y ( Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzen 518055, China); Ma H ( Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzen 518055, China); Teramae N ( Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan.); Sun S ( Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzen 518055, China. Electronic address: sun.shuqing@sz.tsinghua.edu.cn.); He Y ( Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzen 518055, China.)
Abstract	Label-free biosensing based on optical waveguide spectroscopy of silica nanotube (SNT) arrays is realized with high sensitivity. The SNT arrays fabricated using a porous anodic alumina (PAA) template assisted by surface sol-gel (SSG) method showed a high value of 552 reciprocal refractive index unit as the sensing figure of merit by exchanging the sensing environment with water and ethanol. A standard biotin-streptavidin affinity model was tested using the SNT arrays which support a TM1 mode and the fundamental response of the system was investigated. Results show that the response of the SNT arrays for adsorption of streptavidin is higher than the one using substrate without removing the PAA template due to the larger surface area and the stronger electromagnetic field. The limit of detection (LOD) of the SNT arrays for detection of streptavidin was estimated as 93 pM, with the detection time of 40 min. Additionally, the Fresnel calculations suggested higher potential sensitivity of the current system compared to that of the conventional SPR sensors. Thus, the SNT arrays may be used as a versatile platform for high-sensitive label-free optical biosensing due to the high performance and the large potential of the surface functionality.
ISSN	09565663
Volume Number	67
e-ISSN	18734235
Journal	Biosensors and Bioelectronics
Language	English
Publisher	Elsevier
Publisher Date	2015-05-15
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biosensing Techniques Instrumentation Immunoassay Nanotubes Chemistry Silicon Dioxide Streptavidin Analysis Surface Plasmon Resonance Equipment Design Equipment Failure Analysis Ultrastructure Particle Size Staining And Labeling Methods Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry

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