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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rao, Mala Menon, Vishnu |
| Description | Country affiliation: India Author Affiliation: Menon V ( Division of Biochemical Sciences, National Chemical Laboratory, Pune 411 008, India.) |
| Abstract | A bifunctional inhibitor from Penicillium sp VM24 causing inactivation of xyloglucanase from Thermomonospora sp and an aspartic protease from Aspergillus saitoi was identified. Steady state kinetics studies of xyloglucanase and the inhibitor revealed an irreversible, non-competitive, two-step inhibition mechanism with IC(50) and K(i) values of 780 and 500nM respectively. The interaction of o-phthalaldehyde (OPTA)-labeled xyloglucanase with the inhibitor revealed that the inhibitor binds to the active site of the enzyme. Far- and near-UV spectrophotometric analysis suggests that the conformational changes induced in xyloglucanase by the inhibitor may be due to irreversible denaturation of enzyme. The bifunctional inhibitor may have potential as a biocontrol agent for the protection of plants against phytopathogenic fungi. |
| ISSN | 09608524 |
| Volume Number | 123 |
| e-ISSN | 18732976 |
| Journal | Bioresource Technology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Actinomycetales Enzymology Aspartic Acid Proteases Antagonists & Inhibitors Aspergillus Glycoside Hydrolases Penicillium Chemistry Peptides Pharmacology Protease Inhibitors Alkalies Metabolism Circular Dichroism Fusarium Drug Effects Kinetics Least-squares Analysis Microbial Sensitivity Tests Mycelium Growth & Development Rhizopus Spectrometry, Fluorescence Substrate Specificity Temperature Time Factors O-phthalaldehyde Journal Article Research Support, Non-u.s. Gov't Discipline Bioresource |
| Content Type | Text |
| Resource Type | Article |
| Subject | Waste Management and Disposal Medicine Environmental Engineering Renewable Energy, Sustainability and the Environment Bioengineering |
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