NDLI: T-cell receptor gene rearrangements as markers of lineage and clonality in T-cell neoplasms.

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T-cell receptor gene rearrangements as markers of lineage and clonality in T-cell neoplasms.

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T-cell receptor gene rearrangements as markers of lineage and clonality in T-cell neoplasms.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dalla-favera, R. Pelicci, P. G. Bonetti, F. Knowles, D. M. Flug, F.
Abstract	Ig gene rearrangements represent markers of lineage, clonality, and differentiation of B cells, allowing a molecular diagnosis and immunogenotypic classification of B-cell neoplasms. We sought to apply a similar approach to the study of T-cell populations by analyzing rearrangements of the T-cell receptor beta-chain (T beta) gene. Our analysis, by Southern blotting hybridization using T beta-specific probes of DNAs from polyclonal T cells and from 12 T-cell tumors, indicates that T beta gene rearrangement patterns can be used as markers of (i) lineage, allowing the identification of polyclonal T-cell populations, and (ii) clonality, allowing the detection of monoclonal T-cell tumors. In addition, our data indicate that T beta gene rearrangements represent early and general markers of T-cell differentiation since they are detectable in histologically different tumors at all stages of T-cell development. The ability to determine lineage, clonality, and stage of differentiation has significant implications for future experimental and clinical studies on normal and neoplastic T cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	82
Language	English
Publisher	National Academy of Sciences
Publisher Date	1985-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA, Neoplasm Genetics Leukemia Classification Lymphoma Receptors, Antigen, T-Cell T-Lymphocytes Physiology Cell Differentiation Clone Cells DNA Restriction Enzymes Recombination, Genetic Sezary Syndrome Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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