NDLI: A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.

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A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.

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A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Massart, C. Busson, M. Dausset, J. Robbins, E. Lalouel, J. M. Hors, J. Deschamps, I. Cohen, D. Cohen-haguenauer, O.
Abstract	DNA restriction fragments of the genes encoding HLA class II-beta antigens were compared in 34 patients with insulin-dependent diabetes mellitus and 34 HLA-DR-matched healthy individuals. Ninety-three fragments, determined by six restriction enzymes (EcoRI, EcoRV, HindIII, BamHI, Pvu II, and Taq I), were analyzed: (i) A DR Taq I 12.7-kilobase-pair fragment might be a marker for the extended haplotype HLA-B8, DR3. (ii) In controls, DR4 haplotypes are associated with two distinct clusters of DQ restriction fragments (DQR4 and DQR5). Almost all (94%) DR4 patients belong to the DQR4 and not to the DQR5 cluster. This suggests that, among HLA-DR4 haplotypes, only DQR4 haplotypes are involved in susceptibility to insulin-dependent diabetes mellitus. (iii) A DR Taq I 14.5-kilobase-pair fragment was found to be strongly associated with DQR4, mainly in DR3/DR4 heterozygous patients (P = 5 X 10(-4). However, these results must be interpreted with caution, taking into account the high number of statistical tests performed.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	82
Language	English
Publisher	National Academy of Sciences
Publisher Date	1985-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Diabetes Mellitus, Type 1 Genetics Histocompatibility Antigens Class II DNA Restriction Enzymes Immunology Genes HLA-DR Antigens Polymorphism, Genetic Statistics As Topic Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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