NDLI: Alpha/beta T-cell antigen receptor gene and protein expression occurs at early stages of thymocyte differentiation.

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Alpha/beta T-cell antigen receptor gene and protein expression occurs at early stages of thymocyte differentiation.

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Alpha/beta T-cell antigen receptor gene and protein expression occurs at early stages of thymocyte differentiation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Allison, J. P. Mcentire, B. Richie, E. R. Crispe, N. Lanier, L. L. Kimura, J.
Description	Author Affiliation: Richie ER ( University of Texas System Cancer Center, Science Park-Research Division, Smithvile, TX 78957.);
Abstract	Alterations in gene expression that orchestrate eukaryotic cellular differentiation often require appropriate interactions between differentiating cells and a specialized microenvironment. During T-lymphocyte differentiation, immature thymocytes undergo a stringent intrathymic selection process that requires intimate contact with thymic stromal elements. Since this selection process generates T cells that are self-tolerant and recognize nominal antigen only within the context of self-major histocompatibility antigen complex molecules, it is possible that thymocyte/stromal cell interactions are mediated, in part, by antigen-specific receptors expressed on differentiating thymocytes. However, the developmental stage at which alpha/beta antigen-specific receptors are expressed during T-cell maturation has been a matter of debate. To address this issue, we have studied alpha/beta T-cell antigen receptor gene and protein expression on normal thymocyte subsets of AKR/J mice, as well as on a panel of AKR/J primary thymic lymphomas characterized for CD4 (L3T4) and CD8 (Lyt-2) differentiation antigen expression. The data unequivocally demonstrate that alpha/beta heterodimers are expressed not only on phenotypically mature thymocytes but also on the majority of CD4+8+ double-positive cells that comprise the predominant nonmature thymocyte subset. Furthermore, a fraction of thymocytes in the CD4-8- double-negative compartment, known to contain progenitor cells, also expresses readily detectable cell-surface alpha/beta receptors. Therefore, during the process of intrathymic selection, interactions between nonmature thymocytes and stromal cells via the antigen-receptor complex may play a pivotal role in T-cell differentiation and should be considered in formulating schemes for functional T-cell selection.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Receptors, Antigen, T-Cell Genetics T-Lymphocytes Immunology Thymus Gland Cytology Animals Antigens, Differentiation, T-Lymphocyte Antigens, Neoplasm Cell Differentiation Gene Expression Regulation Lymphoma Pathology Mice Mice, Inbred AKR Biosynthesis Receptors, Antigen, T-Cell, Alpha-beta Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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