NDLI: p53 in chronic myelogenous leukemia in acute phase.

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p53 in chronic myelogenous leukemia in acute phase.

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p53 in chronic myelogenous leukemia in acute phase.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cimino, G. Alimena, G. Berrebi, A. Feinstein, E. Kishi, K. Gale, R. P. Berthier, R. Goldman, J. Zaccaria, A. Canaani, E.
Description	Author Affiliation: Feinstein E ( Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.);
Abstract	All patients with chronic myelogenous leukemia (CML) undergo clinical transition from chronic to acute phase. This transition is often associated with deletion of the short arm of chromosome 17 in the form of the i(17q) aberration. Since the p53 gene is a suppressor gene and is located on 17p13, we examined the possibility that it is inactivated during progression of CML. Therefore, we studied the structure and expression of p53 in the leukemic cells of a large number of CML patients in acute phase. We found that although the gene is rarely rearranged, one p53 allele is completely deleted in patients with the i(17q) aberration as well as in some patients who do not show karyotypic changes. In all of these patients the remaining allele is inactivated through loss of expression, rearrangement, or point mutation. Detailed analysis of some patients who carry both p53 alleles indicated neither loss of expression nor structural alterations. It appears that p53 loss of function is associated with progression of around 25% of CML patients.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Rearrangement Genes, Tumor Suppressor Leukemia, Myelogenous, Chronic, BCR-ABL Positive Genetics Leukemia, Myeloid, Acute Mutation Tumor Suppressor Protein P53 Base Composition Cell Line Chromosomes, Human, Pair 22 Chromosomes, Human, Pair 9 Physiopathology Models, Structural Molecular Sequence Data Nucleic Acid Conformation RNA, Neoplasm Isolation & Purification Restriction Mapping Translocation, Genetic Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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