NDLI: Identification of aminopeptidase activity in the secretory granules of mouse mast cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1991 Volume: 88 Issue: 24

Year: 1991 Volume: 88 Issue: 23

Year: 1991 Volume: 88 Issue: 22

Year: 1991 Volume: 88 Issue: 21

Year: 1991 Volume: 88 Issue: 20

Year: 1991 Volume: 88 Issue: 19

Year: 1991 Volume: 88 Issue: 18

Year: 1991 Volume: 88 Issue: 17

Year: 1991 Volume: 88 Issue: 16

Year: 1991 Volume: 88 Issue: 15

Year: 1991 Volume: 88 Issue: 14

Maize oleosin is correctly targeted to seed oil bodies in Brassica napus transformed with the maize oleosin gene.

Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin.

Proteinase trapping: screening for viral proteinase mutants by alpha complementation.

Trans-acting transposase mutant from Tn5.

Retinoic acid is a negative regulator of AP-1-responsive genes.

A P element of Scaptomyza pallida is active in Drosophila melanogaster.

Cytosolic rat brain synapsin I is a diacylglycerol kinase.

Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase.

Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos.

The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner.

Mechanism of intestinal secretion: effect of cyclic AMP on rabbit ileal crypt and villus cells.

Identification and characterization of a ouabain-like compound from human plasma.

Isoprenoid modification of rab proteins terminating in CC or CXC motifs.

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site.

Formation of the complex of bovine papillomavirus E1 and E2 proteins is modulated by E2 phosphorylation and depends upon sequences within the carboxyl terminus of E1.

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

A role for microtubule bundles in the morphogenesis of chicken erythrocytes.

Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase.

Heparin stimulates epidermal growth factor receptor-mediated phosphorylation of tyrosine and threonine residues.

Molecular mimicry by Trypanosoma cruzi: the F1-160 epitope that mimics mammalian nerve can be mapped to a 12-amino acid peptide.

Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia.

Substrate inhibition of the human immunodeficiency virus type 1 reverse transcriptase.

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas.

The Barr body is a looped X chromosome formed by telomere association.

CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x.

Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription.

Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro: effects of combination with colony-stimulating factors.

Direct observation of brownian motion of lipids in a membrane.

Depolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons.

Multiple overlapping homologies between two rheumatoid antigens and immunosuppressive viruses.

Coordinate regulation of HOX genes in human hematopoietic cells.

Molecular cloning and primary structure of Kell blood group protein.

Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor.

Resolution of Holliday junctions in vitro requires the Escherichia coli ruvC gene product.

Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion.

Carbachol-activated muscarinic (M1 and M3) receptors transfected into Chinese hamster ovary cells inhibit trafficking of endosomes.

Human chromosome 16 encodes a factor involved in induction of class II major histocompatibility antigens by interferon gamma.

Molecular structure of Bacillus subtilis aspartate transcarbamoylase at 3.0 A resolution.

C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.

Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins.

The small GTP-binding protein rab4 is associated with early endosomes.

Expression of von Willebrand factor 'Normandy': an autosomal mutation that mimics hemophilia A.

TolA: a membrane protein involved in colicin uptake contains an extended helical region.

Domain of a yeast site-specific recombinase (Flp) that recognizes its target site.

A donor splice mutation and a single-base deletion produce two carboxyl-terminal variants of human serum albumin.

Recent development of the neutral theory viewed from the Wrightian tradition of theoretical population genetics.

Synonymous nucleotide substitution rates in mammalian genes: implications for the molecular clock and the relationship of mammalian orders.

Identification of aminopeptidase activity in the secretory granules of mouse mast cells.

Class I-induced resistance to natural killing: identification of nonpermissive residues in HLA-A2.

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.

Increase in membrane uptake of long-chain fatty acids early during preadipocyte differentiation.

A beta subunit mutation disrupting the catalytic function of Escherichia coli RNA polymerase.

Triple-helix formation by alpha oligodeoxynucleotides and alpha oligodeoxynucleotide-intercalator conjugates.

Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.

Molecular cloning and characterization of the yeast gene for squalene synthetase.

Recombination hotspots in bacteriophage T4 are dependent on replication origins.

Synchronization of oscillatory neuronal responses between striate and extrastriate visual cortical areas of the cat.

1H NMR study of renal trimethylamine responses to dehydration and acute volume loading in man.

A cell cycle-responsive transcriptional control element and a negative control element in the gene encoding DNA polymerase alpha in Saccharomyces cerevisiae.

Crosslinking of hemin to a specific site on the 90-kDa ferritin repressor protein.

Hyperimmune antisera against synthetic peptides representing the glycoprotein of human immunodeficiency virus type 2 can mediate neutralization and antibody-dependent cytotoxic activity.

Nucleotide sequence analysis of Adh genes estimates the time of geographic isolation of the Bogota population of Drosophila pseudoobscura.

Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals.

Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae.

Anionic subsites of the catalytic center of acetylcholinesterase from Torpedo and from cobra venom.

The heme groups of cytochrome o from Escherichia coli.

A copper-thiolate polynuclear cluster in the ACE1 transcription factor.

Interaction of Escherichia coli tRNA(Ser) with its cognate aminoacyl-tRNA synthetase as determined by footprinting with phosphorothioate-containing tRNA transcripts.

Rapid determination of nucleotides that define tRNA(Gly) acceptor identity.

Alu-primed polymerase chain reaction for regional assignment of 110 yeast artificial chromosome clones from the human X chromosome: identification of clones associated with a disease locus.

Determination of the c-MYC DNA-binding site.

Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.

Evidence for non-V3-specific neutralizing antibodies that interfere with gp120/CD4 binding in human immunodeficiency virus 1-infected humans.

Molecular cloning of matrin F/G: A DNA binding protein of the nuclear matrix that contains putative zinc finger motifs.

Mechanism of promoter selection by RNA polymerase II: mammalian transcription factors alpha and beta gamma promote entry of polymerase into the preinitiation complex.

Phosphatidate-dependent protein phosphorylation.

A myogenic factor from sea urchin embryos capable of programming muscle differentiation in mammalian cells.

The number of positively charged amino acids in the basic domain of Tat is critical for trans-activation and complex formation with TAR RNA.

Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system.

Bacterial chemotaxis signaling complexes: formation of a CheA/CheW complex enhances autophosphorylation and affinity for CheY.

Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function.

p53 in chronic myelogenous leukemia in acute phase.

Predicting chemically induced duodenal ulcer and adrenal necrosis with classification trees.

Detection of a key tertiary interaction in the highly conserved GTPase center of large subunit ribosomal RNA.

Post-translational modification of microtubules is a component of synergic alterations of cytoskeleton leading to formation of cytoplasmic processes in fibroblasts.

Interleukin 7 receptor engagement stimulates tyrosine phosphorylation, inositol phospholipid turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes.

Diverse point mutations in the human gene for polymorphic N-acetyltransferase.

Phenotypic plasticity of Schwann cells and enteric glial cells in response to the microenvironment.

Purification of parathyroid hypertensive factor from plasma of spontaneously hypertensive rats.

Year: 1991 Volume: 88 Issue: 13

Year: 1991 Volume: 88 Issue: 12

Year: 1991 Volume: 88 Issue: 11

Year: 1991 Volume: 88 Issue: 10

Year: 1991 Volume: 88 Issue: 9

Year: 1991 Volume: 88 Issue: 8

Year: 1991 Volume: 88 Issue: 7

Year: 1991 Volume: 88 Issue: 6

Year: 1991 Volume: 88 Issue: 5

Year: 1991 Volume: 88 Issue: 4

Year: 1991 Volume: 88 Issue: 3

Year: 1991 Volume: 88 Issue: 2

Year: 1991 Volume: 88 Issue: 1

Two-dimensional life?

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Identification of aminopeptidase activity in the secretory granules of mouse mast cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Serafin, W. E. Stevens, R. L. Guidry, U. A. Kamada, M. M. Austen, K. F. Dayton, E. T.
Description	Author Affiliation: Serafin WE ( Department of Medicine, Harvard Medical School, Boston, MA.);
Abstract	Sonicates of mouse bone marrow-derived mast cells (BMMC) differentiated in vitro and of mouse serosal mast cells differentiated in vivo contained small but approximately equal amounts of aminopeptidase activity, as determined by cleavage of leucine-beta-naphthylamide and resolution of the reaction products by reverse-phase high-performance liquid chromatography. Aminopeptidase activity was exocytosed from antigen-activated, IgE-sensitized BMMC in proportion to the secretory granule enzyme beta-hexosaminidase, thereby localizing approximately 60% of the total cell-associated aminopeptidase activity to the secretory granules of the mast cells. A prominent secretory granule location for aminopeptidase was confirmed by activity measurement in subcellular fractions of disrupted BMMC. The secretory granule aminopeptidase had a pH optimum of 6.0-8.0 and a Km of 0.36 +/- 0.06 mM (mean +/- SD; n = 3) for leucine-beta-naphthylamide. When various amino acid beta-naphthylamides were used as substrates, the preference of the secretory granule enzyme was Ala greater than Leu greater than Phe much greater than Arg much greater than Asp = Tyr. Most of the aminopeptidase activity that was exocytosed from calcium ionophore-activated BMMC was bound to 35S-labeled proteoglycans in complexes of greater than 1 x 10(7) kDa as defined by exclusion during Sepharose CL-2B gel-filtration chromatography. We postulate that the amino-peptidase in the mast cell protease/proteoglycan complexes allows the removal of N-terminal amino acids from peptides that are generated by the action of mast cell endopeptidases.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aminopeptidases Metabolism Cytoplasmic Granules Enzymology Mast Cells Isolation & Purification Animals Cell Fractionation Cells, Cultured Centrifugation, Density Gradient Chromatography, Gel Kinetics Mice Mice, Inbred BALB C Substrate Specificity Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in