NDLI: Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function.

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Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function.

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Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Abraham, R. T. Binstadt, B. A. Uehara, Y. Leibson, P. J. Einspahr, K. J.
Description	Author Affiliation: Einspahr KJ ( Department of Immunology, Mayo Clinic and Foundation, Rochester, MN 55905.);
Abstract	Natural killer (NK) cells are a unique subpopulation of lymphocytes with the capability to kill malignant cells via one of two alternative mechanisms: (i) Fc receptor-dependent cytotoxicity against antibody-coated targets or (ii) direct cell-mediated cytotoxicity. However, the molecular mechanisms that trigger and subsequently regulate NK cell cytotoxicity are incompletely understood. We have therefore investigated the role of protein tyrosine phosphorylation in the transmembrane signaling initiated after Fc receptor stimulation or direct tumor cell contact in clonal CD16+/CD3- human NK cells. We report that stimulation of the Fc receptor rapidly induced the tyrosine phosphorylation of a number of NK cell proteins. These effects occurred within 2 min, were maximal at 10 min, and declined toward baseline after 60 min. In addition, Fc receptor ligation increased the in vitro protein kinase activity of NK cell phosphotyrosyl proteins. We have also demonstrated that direct contact of NK cells with K562 tumor cells induced the rapid phosphorylation of distinct NK cell phosphotyrosyl proteins. Furthermore, the protein-tyrosine kinase inhibitor herbimycin A blocked NK cell cytotoxic function in a concentration-dependent manner. Our results suggest that protein tyrosine phosphorylation is an obligatory early proximal signal in activating the cytotoxic function of NK cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Killer Cells, Natural Immunology Lymphocyte Activation Protein-Tyrosine Kinases Metabolism Signal Transduction Tyrosine Antibiotics, Antineoplastic Pharmacology Antigens, CD Benzoquinones Cell Line Cells, Cultured Clone Cells Cytotoxicity, Immunologic Drug Effects Lactams, Macrocyclic Phosphorylation Quinones Receptors, Fc Rifabutin Analogs & Derivatives Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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