NDLI: The small GTP-binding protein rab4 is associated with early endosomes.

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The small GTP-binding protein rab4 is associated with early endosomes.

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The small GTP-binding protein rab4 is associated with early endosomes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zahraoui, A. Mellman, I. Van Der Sluijs, P. Goud, B. Hull, M. Tavitian, A.
Description	Author Affiliation: Van Der Sluijs P ( Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.);
Abstract	Small GTP-binding proteins of the rab family have been implicated as playing important roles in controlling membrane traffic on the biosynthetic and endocytic pathways. We demonstrate that a distinct rab protein, rab4p, is associated with the population of early endosomes involved in transferrin-receptor recycling. An antibody to human rab4p was found to detect a doublet of approximately 24-kDa proteins on immunoblots from various cell types. Seventy-five percent of these proteins were tightly membrane bound and could be released only by detergent treatment. Upon isolation of early endosomes, late endosomes, and lysosomes, by free-flow electrophoresis and Percoll density-gradient centrifugation, most (70%) of the rab4p was found to cofractionate with early endosomes and endocytic vesicles containing 125I-labeled transferrin. The rab proteins previously localized to the endoplasmic reticulum and/or Golgi apparatus were not found in these fractions. We also localized rab4p to transferrin-receptor-containing early endosomes by immunofluorescence after expression of rab4 cDNA. The association of rab4p with early endosomes and other vesicles involved in the intracellular transport of transferrin receptor suggests that rab4p may play a role in regulating the pathway of receptor recycling.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Endocytosis GTP-Binding Proteins Metabolism Animals Antibodies Cell Fractionation Cell Line Endoplasmic Reticulum Ultrastructure Fluorescent Antibody Technique Isolation & Purification Golgi Apparatus HeLa Cells Horseradish Peroxidase Intracellular Membranes Microsomes Rab4 GTP-Binding Proteins Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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