NDLI: Influence of dimethyl myleran on tolerance induction and immune function in major histocompatibility complex-haploidentical murine bone-marrow transplantation.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1991 Volume: 88 Issue: 24

Year: 1991 Volume: 88 Issue: 23

Year: 1991 Volume: 88 Issue: 22

Year: 1991 Volume: 88 Issue: 21

Year: 1991 Volume: 88 Issue: 20

Year: 1991 Volume: 88 Issue: 19

Theory of symmetry classes.

Stimulation of pheromone biosynthesis in the moth Helicoverpa zea: action of a brain hormone on pheromone glands involves Ca2+ and cAMP as second messengers.

Isolation, sequence analysis, and physiological properties of enkephalins in the nervous tissue of the shore crab Carcinus maenas L.

On the stability of dispensable constituents of the eukaryotic genome: stability of coding sequences versus truly hypervariable sequences in a clonal vertebrate, the amazon molly, Poecilia formosa.

Rapid changes of protein phosphorylation are involved in transduction of the elicitor signal in plant cells.

Chlorobenzoate catabolic transposon Tn5271 is a composite class I element with flanking class II insertion sequences.

Hyaluronic acid capsule is a virulence factor for mucoid group A streptococci.

Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse.

Expression of proteins encoded by Epstein-Barr virus trans-activator genes depends on the differentiation of epithelial cells in oral hairy leukoplakia.

Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein.

Demonstration of a 1,25-dihydroxyvitamin D3-responsive protein in human lymphocytes: immunologic crossreactivity and inverse regulation with the vitamin D receptor.

A method for production of antibodies to human T-cell receptor beta-chain variable regions.

Retroviral-mediated gene transfer into hepatocytes in vivo.

Direct evidence for in vivo hydroxyl-radical generation in experimental iron overload: an ESR spin-trapping investigation.

Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.

Targeting of transgene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies.

Precise localization of the alpha-globin gene cluster within one of the 20- to 300-kilobase DNA fragments released by cleavage of chicken chromosomal DNA at topoisomerase II sites in vivo: evidence that the fragments are DNA loops or domains.

Adrenocorticotropin receptors: functional expression from rat adrenal mRNA in Xenopus laevis oocytes.

The T-cell-receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal.

Expression of two human beta-adrenergic receptors in Escherichia coli: functional interaction with two forms of the stimulatory G protein.

Distinct pathways for basolateral targeting of membrane and secretory proteins in polarized epithelial cells.

Locations of Arg-82, Asp-85, and Asp-96 in helix C of bacteriorhodopsin relative to the aqueous boundaries.

Cholesterol-induced fluid-phase immiscibility in membranes.

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.

Production of leukotrienes in gonadotropin-releasing hormone-stimulated pituitary cells: potential role in luteinizing hormone release.

Tonic inhibition and rebound facilitation of a neuronal calcium channel by a GTP-binding protein.

An unusual mechanism for resistance to the antibiotic coumermycin A1.

Involvement of corticotropin-releasing factor in chronic stress regulation of the brain noradrenergic system.

Cell-free transcription directed by the 422 adipose P2 gene promoter: activation by the CCAAT/enhancer binding protein.

HLA-DR and -DQ gene polymorphism in West Africans is twice as extensive as in north European Caucasians: evolutionary implications.

Conventional antigen and superantigen may be coupled to distinct and cooperative T-cell activation pathways.

Extensive mitochondrial diversity within a single Amerindian tribe.

Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell death.

High-level expression of rat PC12 tyrosine hydroxylase cDNA in Escherichia coli: purification and characterization of the cloned enzyme.

Molecular cloning of a putative receptor protein kinase gene encoded at the self-incompatibility locus of Brassica oleracea.

Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack.

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

Coexpression of alpha 1 with putative beta 3 subunits results in functional Na+/K+ pumps in Xenopus oocytes.

Retroviral-like element in a marine invertebrate.

Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 88 Issue: 19)

Dual activation of a sex pheromone-dependent ion channel from insect olfactory dendrites by protein kinase C activators and cyclic GMP.

Characterization of a neu/c-erbB-2 protein-specific activating factor.

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.

Acidic fibroblast growth factor promotes vascular repair.

Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.

Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism.

Galanin inhibits a dihydropyridine-sensitive Ca2+ current in the RINm5f cell line.

Retrotransposition of a mouse L1 element.

Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication.

Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine.

Influence of dimethyl myleran on tolerance induction and immune function in major histocompatibility complex-haploidentical murine bone-marrow transplantation.

SOS-inducible DNA repair proteins, RuvA and RuvB, of Escherichia coli: functional interactions between RuvA and RuvB for ATP hydrolysis and renaturation of the cruciform structure in supercoiled DNA.

Immunoregulatory activity of the T-cell receptor alpha chain demonstrated by retroviral gene transfer.

A PCR procedure to determine the sequence of large polypeptides by rapid walking through a cDNA library.

Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs.

Human bone marrow non-B, non-T cells produce interleukin 4 in response to cross-linkage of Fc epsilon and Fc gamma receptors.

T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function.

Protective effect of medroxyprogesterone acetate plus testosterone against radiation-induced damage to the reproductive function of male rats and their offspring.

RNA-mediated ligation of self-cleavage products of a Neurospora mitochondrial plasmid transcript.

Mechanism of synergistic transcriptional transactivation by the human glucocorticoid receptor.

Ultraviolet irradiation of DNA complexed with alpha/beta-type small, acid-soluble proteins from spores of Bacillus or Clostridium species makes spore photoproduct but not thymine dimers.

E1BF is an essential RNA polymerase I transcription factor with an intrinsic protein kinase activity that can modulate rRNA gene transcription.

Moesin: a member of the protein 4.1-talin-ezrin family of proteins.

Physical map of human Xq27-qter: localizing the region of the fragile X mutation.

Molecular characterization of mild-to-moderate hemophilia A: detection of the mutation in 25 of 29 patients by denaturing gradient gel electrophoresis.

Expression of biologically active heterodimeric bovine follicle-stimulating hormone in milk of transgenic mice.

Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10.

Haplotypes of the steroid 21-hydroxylase gene region encoding mild steroid 21-hydroxylase deficiency.

Effects of injected Alzheimer beta-amyloid cores in rat brain.

The position of the microtubule-organizing center in directionally migrating fibroblasts depends on the nature of the substratum.

31P saturation transfer and phosphocreatine imaging in the monkey brain.

Evolution of aminoacyl-tRNA synthetase quaternary structure and activity: Saccharomyces cerevisiae mitochondrial phenylalanyl-tRNA synthetase.

Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations.

Structural determinants of stereospecificity in yeast alcohol dehydrogenase.

Endocytosis by the asialoglycoprotein receptor is independent of cytoplasmic serine residues.

Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa.

Catalytic properties of an Escherichia coli formate dehydrogenase mutant in which sulfur replaces selenium.

Architectural rules of the zinc-finger motif: comparative two-dimensional NMR studies of native and 'aromatic-swap' domains define a 'weakly polar switch'.

A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase.

Identification and partial characterization of six members of the kinesin superfamily in Drosophila.

Interleukin 1 is processed and released during apoptosis.

The large form of hepatitis delta antigen is crucial for assembly of hepatitis delta virus.

Isolation of a murine osteoclast colony-stimulating factor.

Sp1-dependent activation of a synthetic promoter by human immunodeficiency virus type 1 Tat protein.

Baculovirus-mediated expression of human apolipoprotein E in Manduca sexta larvae generates particles that bind to the low density lipoprotein receptor.

Vitamin D3 binding protein (group-specific component) is a precursor for the macrophage-activating signal factor from lysophosphatidylcholine-treated lymphocytes.

Inhibition of acute inflammation in the periphery by central action of salicylates.

A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin.

ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene.

Polymorphic sites in the African population detected by sequence analysis of the glucose-6-phosphate dehydrogenase gene outline the evolution of the variants A and A-.

Human gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death.

Ligand-binding and heterodimerization activities of a conserved region in the ligand-binding domain of the thyroid hormone receptor.

Regulated expression of the GAL4 activator gene in yeast provides a sensitive genetic switch for glucose repression.

Complementation of snf1, a mutation affecting global regulation of carbon metabolism in yeast, by a plant protein kinase cDNA.

A single base deletion in the Tfm androgen receptor gene creates a short-lived messenger RNA that directs internal translation initiation.

Mammalian Sec23p homologue is restricted to the endoplasmic reticulum transitional cytoplasm.

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

Enzymatic modification of proteins with a geranylgeranyl isoprenoid.

A second thrombospondin gene in the mouse is similar in organization to thrombospondin 1 but does not respond to serum.

A soluble, single-chain T-cell receptor fragment endowed with antigen-combining properties.

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

A different perception of the linear, nonthreshold hypothesis for low-dose irradiation.

Protein-DNA interactions in vivo of an erythroid-specific, human beta-globin locus enhancer.

Metabolic rate of membrane-permeant diacylglycerol and its relation to human resting T-lymphocyte activation.

Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.

Self peptide requirement for class II major histocompatibility complex allorecognition.

Induction of plasmacytomas secreting antigen-specific monoclonal antibodies with a retrovirus expressing v-abl and c-myc.

Expression of the rat growth hormone-releasing hormone gene in placenta is directed by an alternative promoter.

Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.

X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution.

Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction.

Secreted acid phosphatase of Leishmania mexicana: a filamentous phosphoglycoprotein polymer.

In vivo catalysis of a metabolically essential reaction by an antibody.

Germ-cell deficient (gcd), an insertional mutation manifested as infertility in transgenic mice.

The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA.

Nerve growth factor prevents the amblyopic effects of monocular deprivation.

Studies on DNA-cleaving agents: computer modeling analysis of the mechanism of activation and cleavage of dynemicin-oligonucleotide complexes.

Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa.

Year: 1991 Volume: 88 Issue: 18

Year: 1991 Volume: 88 Issue: 17

Year: 1991 Volume: 88 Issue: 16

Year: 1991 Volume: 88 Issue: 15

Year: 1991 Volume: 88 Issue: 14

Year: 1991 Volume: 88 Issue: 13

Year: 1991 Volume: 88 Issue: 12

Year: 1991 Volume: 88 Issue: 11

Year: 1991 Volume: 88 Issue: 10

Year: 1991 Volume: 88 Issue: 9

Year: 1991 Volume: 88 Issue: 8

Year: 1991 Volume: 88 Issue: 7

Year: 1991 Volume: 88 Issue: 6

Year: 1991 Volume: 88 Issue: 5

Year: 1991 Volume: 88 Issue: 4

Year: 1991 Volume: 88 Issue: 3

Year: 1991 Volume: 88 Issue: 2

Year: 1991 Volume: 88 Issue: 1

Two-dimensional life?

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Influence of dimethyl myleran on tolerance induction and immune function in major histocompatibility complex-haploidentical murine bone-marrow transplantation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ishii, E. Gengozian, N. Good, R. A.
Description	Author Affiliation: Ishii E ( Department of Pediatrics, All Children's Hospital, University of South Florida, St. Petersburg 33701.);
Abstract	To study murine major histocompatibility complex (MHC)-haploidentical bone-marrow transplantation (BMT), B6C3F1 mice (H-2b/k) underwent BMT using syngeneic [B6C3F1 (H-2b/k)], haploidentical [CB6F1 (H-2d/b)], or fully allogeneic [DBA/2 (H-2d)] donor mice. As pretreatment, dimethyl myleran (DMM), an alkylating agent that produces effective myeloablation but little immunosuppression, was used with total body irradiation (TBI). Four conditioning regimens were studied: TBI 800 rads (1 rad = 0.01 Gy), TBI 950 rads, TBI 800 rads plus DMM (0.2 mg per mouse), and TBI 950 rads plus DMM. Survival rates, chimerism, proliferative responses in mixed-lymphocyte culture, specific cell-mediated lympholysis, and in vivo plaque-forming cell responses to several antigens were compared. TBI 800 rads plus DMM was maximally effective. Haploidentical BMT was as successful in inducing long-term survival and immune and hematologic reconstitution as was syngeneic BMT. This regimen plus haploidentical BMT of T-cell-purged marrow yielded survivors tolerant of donor and recipient major histocompatibility complex. Such myeloablation and immunosuppression prevented graft rejection, immunodeficiency due to histoincompatibility, and damage to a radiosensitive cell population. A microenvironmental influence crucial to some antibody responses was thus revealed. Delayed recovery of antibody production after BMT in humans may be due partly to suboptimal myeloablation or excess irradiation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bone Marrow Transplantation Immunology Busulfan Analogs & Derivatives Immune Tolerance Drug Effects Animals Antibody Formation Pharmacology Cytotoxicity, Immunologic Immunity, Cellular Lymphocyte Culture Test, Mixed Major Histocompatibility Complex Mice Mice, Inbred Strains Radiation Chimera Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in