NDLI: Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras.

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Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras.

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Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Buerki, K. Nemazee, D.
Description	Author Affiliation: Nemazee D ( Basel Institute for Immunology, Switzerland.);
Abstract	To study the fate of developing B cells in the presence and absence of the autoantigens to which they react, chimeric mice were constructed by injecting bone marrow cells from mice transgenic for rearranged immunoglobulin genes encoding an anti-H-2Kk antibody into irradiated recipients that did or did not express the H-2Kk antigen. In the presence of H-2Kk, the anti-H-2Kk-specific B cells were deleted from the spleen and lymph nodes, whereas in its absence, anti-H-2Kk cells were abundant. B cells bearing a low level of membrane immunoglobulin with the anti-H-2Kk idiotype were found in the bone marrows of H-2Kk recipients, suggesting that clonal deletion of autoreactive cells was occurring in the pre-B-cell to B-cell transitional stage of B-cell development.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-Lymphocytes Immunology Bone Marrow Transplantation Bone Marrow Immune Tolerance Major Histocompatibility Complex Animals Antibodies, Monoclonal Chimera Clone Cells Fluorescent Antibody Technique H-2 Antigens Genetics Immunoglobulin Idiotypes Immunoglobulin M Mice Mice, Inbred Strains Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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