NDLI: Retrotransposition of a mouse L1 element.

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Retrotransposition of a mouse L1 element.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Evans, J. P. Palmiter, R. D.
Description	Author Affiliation: Evans JP ( Department of Medical Genetics, Howard Hughes Medical Institute, University of Washington, Seattle 98195.);
Abstract	Long interspersed elements (LINEs) of the L1 family represent a major class of mammalian repetitive DNA and are present at copy numbers of between 10(4) and 10(5) elements per genome. Structural similarities between L1 elements and known retrotransposons have led to the suggestion that a subset of L1 elements may function as mobile genetic elements and have thus gained their prominent place in the mammalian genome. We describe a consensus mouse L1 element that was tagged with a heterologous intron and shown to transpose by way of an RNA intermediate when transfected into baby hamster kidney cells, formally establishing L1 elements as retrotransposons. When the putative reverse transcriptase-encoding region of this L1 element was deleted, the element still underwent retrotransposition in hamster cells, suggesting that reverse transcriptase activity can be supplied by an endogenous enzyme.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Transposable Elements Mice Genetics Repetitive Sequences, Nucleic Acid Retroviridae Animals Blotting, Southern Cricetinae Gene Expression Genetic Complementation Test Polymerase Chain Reaction Promoter Regions, Genetic RNA Metabolism Restriction Mapping Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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