NDLI: T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function.

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T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function.

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T-cell receptor alpha chain plays a critical role in antigen-specific suppressor cell function.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Byrne, M. C. Whitters, M. J. Greenfield, E. Collins, M. O'hara, R. M. Kuchroo, V. K. Dorf, M. E. Atsumi, Y. Connolly, J. B.
Description	Author Affiliation: Kuchroo VK ( Department of Pathology, Harvard Medical School, Boston MA 02115.);
Abstract	Antigen-specific suppressor T-cell hybridomas release soluble suppressor factors (TsF) in the supernatant that modulate both in vivo delayed-type hypersensitivity and in vitro plaque-forming cell responses in an antigen-specific manner. To study the relationship between the T-cell receptor (TcR) and TsF, we developed a series of TcR alpha- or TcR beta- expression variants from suppressor T-cell hybridomas that expressed the CD3-TcR alpha/beta complex. We demonstrate that loss of TcR alpha but not TcR beta mRNA was accompanied by the concomitant loss of suppressor bioactivity. Homologous transfection of TcR alpha cDNA into a TcR alpha- beta+ clone reconstituted both CD3-TcR expression and suppressor function. Furthermore, suppressor activity from TcR beta- variants was specifically absorbed by antigen and anti-TcR alpha antibodies, but not by anti-CD3 or anti-TcR beta affinity columns. These data directly establish a role for the TcR alpha chain in suppressor T-cell function and suggest that the TcR alpha chain is part of the antigen-specific TsF molecule.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Receptors, Antigen, T-Cell, Alpha-beta Physiology Suppressor Factors, Immunologic Immunology T-Lymphocytes, Regulatory Animals Antibody Formation Antigens Antigens, CD3 Antigens, Differentiation, T-Lymphocyte Blotting, Northern DNA Genetics Gene Expression Hybridomas Hypersensitivity, Delayed Mice Molecular Sequence Data Oligonucleotides Chemistry Polymerase Chain Reaction RNA, Messenger Receptors, Antigen, T-Cell Transfection Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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