NDLI: Interleukin 1 is processed and released during apoptosis.

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Interleukin 1 is processed and released during apoptosis.

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Two-dimensional life?

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Interleukin 1 is processed and released during apoptosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hogquist, K. A. Unanue, E. R. Nett, M. A. Chaplin, D. D.
Description	Author Affiliation: Hogquist KA ( Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.);
Abstract	Interleukin (IL-) 1 alpha and 1 beta are synthesized as 31- to 34-kDa pro molecules. They are released from monocytes and macrophages as proteolytically processed 17-kDa mature molecules that bind with high affinity to specific receptors on target cells. IL-1 is not released via the classic secretory pathway. The pro molecules are synthesized as cytosolic proteins without signal peptides. Although the proteases that convert the pro molecules to the mature forms are cytosolic enzymes, processed IL-1 is not detected associated with the cell but is found only in culture supernatants. We demonstrate here that release of IL-1 is efficiently induced by cell injury. When the injury causes cellular necrosis, IL-1 alpha is released as a mixture of unprocessed and processed molecules but IL-1 beta is released exclusively as the biologically inactive pro form. In contrast, when cells undergo apoptosis, maturation of both IL-1 alpha and IL-1 beta is efficient. When apoptosis is rapid, as in macrophages that are targets for allospecific cytotoxic T lymphocytes, processing is observed to occur intracellularly. These findings suggest that cell injury is an important physiologic stimulus for release of IL-1. The nature of the injury profoundly affects the forms of IL-1 that are released.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Survival Interleukin-1 Metabolism Animals DNA Damage Macrophages Immunology Mice Mice, Inbred Strains Monocytes Necrosis Peritoneal Cavity Cytology Protein Processing, Post-Translational T-Lymphocytes, Cytotoxic Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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