NDLI: Induction of plasmacytomas secreting antigen-specific monoclonal antibodies with a retrovirus expressing v-abl and c-myc.

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Induction of plasmacytomas secreting antigen-specific monoclonal antibodies with a retrovirus expressing v-abl and c-myc.

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Induction of plasmacytomas secreting antigen-specific monoclonal antibodies with a retrovirus expressing v-abl and c-myc.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mischak, H. Weissinger, E. M. Risser, R. Largaespada, D. A. Mitchell, T. Kaehler, D. A. Smith-gill, S. J. Mushinski, J. F.
Description	Author Affiliation: Weissinger EM ( Molecular Genetics Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.);
Abstract	ABL-MYC, a recombinant murine retrovirus that expresses v-abl and c-myc, rapidly induces transplantable mono- or oligoclonal plasmacytomas in BALB/c mice. To determine if the targets for transformation of this retrovirus are antigen-committed B lymphocytes and to explore this system as an alternative technique for producing antigen-specific monoclonal antibodies, plasmacytomas were induced in mice that had been immunized with two different types of immunogens, hen egg white lysozyme and sheep red blood cells. The majority of these plasmacytomas secreted immunogen-specific antibodies. Plasmacytomas induced in unimmunized mice did not react with hen egg white lysozyme or sheep red blood cells. The specific antibodies were comparable in concentration, specificity, and affinity to monoclonal antibodies obtained with conventional hybridoma technology, but, in addition to IgGs and IgMs, they included specific IgA antibodies, which are rare among splenic-derived hybridomas. Our results demonstrate that a principal target for ABL-MYC is an antigen-committed B lymphocyte. In addition this procedure provides an alternative method for the production of monoclonal antibodies, without a requirement for hetero-caryon formation by cell fusion techniques.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Monoclonal Immunology Plasmacytoma Animals Antibody Specificity Blotting, Northern Blotting, Southern Gene Expression Mice Mice, Inbred BALB C Muramidase Oncogene Proteins V-abl Genetics Oncogenes Proto-Oncogene Proteins C-myc Proto-Oncogenes RNA, Messenger Retroviridae Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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