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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Teichroew, D. Ungar, D. Chan, Y. Strahler, J. R. Kuick, R. Hailat, N. Keim, D. R. Neel, J. V. Gratiot-deans, J. Hanash, S. M. |
| Description | Author Affiliation: Hanash SM ( Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor.); |
| Abstract | We have developed a data base of lymphoid proteins detectable by two-dimensional polyacrylamide gel electrophoresis. The data base contains two-dimensional patterns and derived information pertaining to polypeptide constituents of unstimulated and stimulated mature T cells and immature thymocytes, single-cell-derived T- and B-cell clones, leukemia cells, and lymphoid cell lines. Using this data base, we have compared the protein constituents of mature T cells and immature thymocytes before and after mitotic stimulation. A subset of polypeptides that are induced in mature T cells following mitotic stimulation were found to be constitutively expressed in immature thymocytes. Other polypeptides exhibited differences in their expression between mature and immature thymocytes in a manner unrelated to proliferation. The identity of several constitutively expressed or mitotically induced proteins in lymphoid cells was established by microsequencing. These initial findings point to significant differences in the molecular pathways leading to proliferation between mature and immature T cells. The construction of this database should facilitate further studies of lymphoid differentiation and function. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 90 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1993-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Databases, Factual Lymphocyte Activation Proteins Genetics T-Lymphocytes Physiology Thymus Gland Amino Acid Sequence Antigens, CD4 Antigens, CD8 Cell Differentiation Child, Preschool Electrophoresis, Gel, Two-Dimensional Enzymes Molecular Sequence Data Isolation & Purification T-Lymphocyte Subsets Immunology Cytology Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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