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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Seth, A. Gupta, S. Davis, R. J. |
| Description | Author Affiliation: Gupta S ( Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605.); |
| Abstract | The product of the human c-myc protooncogene (Myc) is a sequence-specific DNA binding protein. Here, we demonstrate that the placement of the specific Myc DNA binding site CACGTG upstream of a luciferase reporter gene conferred Myc-stimulated expression that was inhibited by the overexpression of the basic-helix-loop-helix/leucine zipper protein Max. It was observed that Myc was phosphorylated in vivo within the NH2-terminal domain at Thr-58 and Ser-62. Replacement of these phosphorylation sites with Ala residues caused a marked decrease in Myc-stimulated reporter gene expression. In contrast, the replacement of Thr-58 or Ser-62 with an acidic residue (Glu) caused only a small inhibition of transactivation. Together, these data demonstrate that the NH2-terminal phosphorylation sites Thr-58 and Ser-62 are required for high levels of transactivation of gene expression by Myc. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 90 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1993-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Mutagenesis, Site-Directed Protein Kinases Metabolism Proto-Oncogene Proteins C-myc Serine Threonine Transcriptional Activation Amino Acid Sequence Animals Calcium-Calmodulin-Dependent Protein Kinases Cell Line Cercopithecus Aethiops Codon DNA Genetics Gene Expression Genes, Myc Molecular Sequence Data Oligodeoxyribonucleotides Phosphorylation Plasmids Point Mutation Polymerase Chain Reaction Substrate Specificity Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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