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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Buchan, H. L. Yang, T. Craig, R. W. Kozopas, K. M. Zhou, P. |
| Description | Author Affiliation: Kozopas KM ( Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.); |
| Abstract | During their lifespan, immature cells normally pass through sequential transitions to a differentiated state and eventually undergo cell death. This progression is aberrant in cancer, although the transition to differentiation can be reestablished in inducible leukemia cell lines. This report describes a gene, MCL1, that we isolated from the ML-1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Our results demonstrate that expression of MCL1 increases early in the induction, or 'programming,' of differentiation in ML-1 (at 1-3 hr), before the appearance of differentiation markers and mature morphology (at 1-3 days). They further show that MCL1 has sequence similarity to BCL2, a gene involved in normal lymphoid development and in lymphomas with the t(14;18) chromosome translocation. MCL1 and BCL2 do not fall into previously known gene families. BCL2 differs from many oncogenes in that it inhibits programmed cell death, promoting viability rather than proliferation; this parallels the association of MCL1 with the programming of differentiation and concomitant maintenance of viability but not proliferation. Thus, in contrast to proliferation-associated genes, expression of MCL1 and BCL2 relates to the programming of differentiation and cell viability/death. The discovery of MCL1 broadens our perspective on an emerging MCL1/BCL2 gene family and will allow further comparison with oncogene families. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 90 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1993-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Differentiation Genetics Neoplasm Proteins Proto-Oncogene Proteins Proto-Oncogenes Amino Acid Sequence Drug Effects Cloning, Molecular DNA, Neoplasm Isolation & Purification Gene Expression Kinetics Leukemia, Myeloid Molecular Sequence Data Myeloid Cell Leukemia Sequence 1 Protein Poly A Protein-Tyrosine Kinases Proto-Oncogene Proteins C-bcl-2 RNA RNA, Messenger Metabolism Sequence Homology, Amino Acid Tetradecanoylphorbol Acetate Pharmacology Tumor Cells, Cultured Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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