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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jackson, V. Lazenby, A. Hamada, H. Brose, K. Dranoff, G. Pardoll, D. Golumbek, P. Mulligan, R. C. Jaffee, E. Levitsky, H. |
| Description | Author Affiliation: Dranoff G ( Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.); |
| Abstract | To compare the ability of different cytokines and other molecules to enhance the immunogenicity of tumor cells, we generated 10 retroviruses encoding potential immunomodulators and studied the vaccination properties of murine tumor cells transduced by the viruses. Using a B16 melanoma model, in which irradiated tumor cells alone do not stimulate significant anti-tumor immunity, we found that irradiated tumor cells expressing murine granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulated potent, long-lasting, and specific anti-tumor immunity, requiring both CD4+ and CD8+ cells. Irradiated cells expressing interleukins 4 and 6 also stimulated detectable, but weaker, activity. In contrast to the B16 system, we found that in a number of other tumor models, the levels of anti-tumor immunity reported previously in cytokine gene transfer studies involving live, transduced cells could be achieved through the use of irradiated cells alone. Nevertheless, manipulation of the vaccine or challenge doses made it possible to demonstrate the activity of murine GM-CSF in those systems as well. Overall, our results have important implications for the clinical use of genetically modified tumor cells as therapeutic cancer vaccines. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 90 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1993-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Carcinoma, Renal Cell Immunology Colonic Neoplasms Fibrosarcoma Granulocyte-Macrophage Colony-Stimulating Factor Secretion Immunization Kidney Neoplasms Lung Neoplasms Melanoma, Experimental Transfection Animals Antibodies, Monoclonal Antigens, CD4 Antigens, CD8 Prevention & Control Cell Adhesion Molecules Genetics Genetic Vectors Intercellular Adhesion Molecule-1 Lymphocyte Depletion Mice Mice, Inbred BALB C Mice, Inbred C57BL Retroviridae T-Lymphocyte Subsets Tumor Cells, Cultured Radiation Effects Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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