NDLI: Kinetics of mature T-cell development in the thymus.

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Kinetics of mature T-cell development in the thymus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Egerton, M. Scollay, R. Shortman, K.
Description	Author Affiliation: Egerton M ( Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.);
Abstract	We have reexamined the balance between cell birth, cell maturation, and cell death in the thymus by labeling dividing thymocytes and their progeny in vivo with [3H]-thymidine, isolating clearly defined subpopulations by fluorescence-activated cell sorting, and determining the distribution of label by autoradiography. When mature thymocytes were precisely defined (as CD4+CD8- CD3+ or CD4-CD8+ CD3+) and separated from immature single positives (CD4+CD8- CD3- and CD4-CD8+ CD3-), a lag was observed in the rate of entry of [3H]thymidine into mature cells. Thus, many of the mature thymocytes appear to derive from a small nondividing cortical thymocyte pool, rather than originating directly from the earliest dividing CD4+CD8+ blasts. There was little evidence for cell division during or after mature thymocyte formation, suggesting a one-for-one differentiation from cortical cells rather than selective clonal expansion. The rate of production of mature single positive thymocytes agreed closely with estimates of the rate of export of mature T cells from the thymus and was only 3% of the rate of production of double-positive cortical thymocytes. This was compatible with a stringent selection process and extensive intrathymic cell death and suggested that no extensive negative selection occurred after the mature cells were formed.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	T-Lymphocytes Immunology Thymus Gland Animals Antigens, CD3 Antigens, CD4 Antigens, CD8 Antigens, Differentiation, T-Lymphocyte Cell Division DNA Replication Kinetics Mice Mice, Inbred CBA Receptors, Antigen, T-Cell Cytology Thymidine Metabolism Tritium Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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