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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Middleton, P. Mumby, S. M. Linder, M. E. Hepler, J. R. Taussig, R. Gilman, A. G. |
| Description | Author Affiliation: Linder ME ( Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas 75235.); |
| Abstract | A small number of membrane-associated proteins are reversibly and covalently modified with palmitic acid. Palmitoylation of G-protein alpha and beta subunits was assessed by metabolic labeling of subunits expressed in simian COS cells or insect Sf9 cells. The fatty acid was incorporated into all of the alpha subunits examined (alpha s, alpha o, alpha i1, alpha i2, alpha i3, alpha z, and alpha q), including those that are also myristoylated (alpha o, alpha i, and alpha z). Palmitate was released by treatment with base, suggesting attachment to the protein through a thioester or ester bond. Limited tryptic digestion of activated alpha o and alpha s resulted in release of the amino-terminal portions of the proteins and radioactive palmitate. These data are consistent with palmitoylation of the proteins near their amino termini, most likely on Cys-3. Reversible acylation of G-protein alpha subunits may provide an additional mechanism for regulation of signal transduction. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 90 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1993-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | GTP-Binding Proteins Genetics Metabolism Palmitic Acids Protein Processing, Post-Translational Animals Autoradiography Cell Line Cell Membrane Cercopithecus Aethiops Cytosol Isolation & Purification Guanosine 5'-O-(3-Thiotriphosphate) Macromolecular Substances Methionine Molecular Sequence Data Moths Myristic Acid Myristic Acids Oligodeoxyribonucleotides Palmitic Acid Plasmids Recombinant Proteins Biosynthesis Transfection Tritium Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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