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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dewald, B. Baggiolini, M. Geiser, T. Clark-lewis, I. Moser, B. |
| Description | Author Affiliation: Clark-Lewis I ( Biomedical Research Center, University of British Columbia, Vancouver, Canada.); |
| Abstract | Amino acid deletion and mutagenesis experiments have indicated that the sequences Glu-Leu-Arg (ELR) preceding the first cysteine at the N terminus of interleukin 8 (IL-8) is required for receptor binding and neutrophil activation. Platelet factor 4 (PF4) is structurally related to IL-8 (35% sequence identity) but lacks the N-terminal ELR sequence and comparable effects on neutrophils. We introduced the ELR sequence at the N terminus of PF4 and found that the modified protein was a potent neutrophil activator and attractant. On the other hand, when the ELR sequence was introduced into the corresponding positions of two other proteins related to IL-8, gamma-interferon-inducible protein IP10 and monocyte chemoattractant protein 1, neither of them acquired neutrophil-activating properties, indicating that besides ELR additional structural determinants of IL-8 and PF4 are important for binding to IL-8 receptors. The conservation of these binding determinants suggests that PF4 may have evolved from a neutrophil activating protein. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 90 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1993-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Neutrophils Physiology Platelet Factor 4 Metabolism Pharmacology Receptors, Immunologic Amino Acid Sequence Calcium Blood Chemotaxis, Leukocyte Drug Effects Cytochalasin B Cytosol Dose-Response Relationship, Drug In Vitro Techniques Interleukin-8 Kinetics Leukocyte Elastase Molecular Sequence Data Pancreatic Elastase Chemical Synthesis Genetics Receptors, Interleukin-8A Sequence Homology, Amino Acid Structure-Activity Relationship Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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