NDLI: Nucleotide sequence of the human N-myc gene.

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Nucleotide sequence of the human N-myc gene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schwab, M. Stanton, L. W. Bishop, J. M.
Abstract	Human neuroblastomas frequently display amplification and augmented expression of a gene known as N-myc because of its similarity to the protooncogene c-myc. It has therefore been proposed that N-myc is itself a protooncogene, and subsequent tests have shown that N-myc and c-myc have similar biological activities in cell culture. We have now detailed the kinship between N-myc and c-myc by determining the nucleotide sequence of human N-myc and deducing the amino acid sequence of the protein encoded by the gene. The topography of N-myc is strikingly similar to that of c-myc: both genes contain three exons of similar lengths; the coding elements of both genes are located in the second and third exons; and both genes have unusually long 5' untranslated regions in their mRNAs, with features that raise the possibility that expression of the genes may be subject to similar controls of translation. The resemblance between the proteins encoded by N-myc and c-myc sustains previous suspicions that the genes encode related functions.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Oncogenes Proto-Oncogene Proteins Genetics Proto-Oncogenes Amino Acid Sequence Cell Transformation, Neoplastic DNA Gene Amplification Gene Expression Regulation Neuroblastoma Poly A Physiology Proto-Oncogene Proteins C-myc RNA, Messenger RNA, Neoplasm Sequence Homology, Nucleic Acid Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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