NDLI: Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila.

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Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	García-bellido, A. Barrio, R. Del Arco, A. De Celis, J. F.
Description	Author Affiliation: de Celis JF ( Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Spain.);
Abstract	The Drosophila Notch gene product is a transmembrane protein that functions as a receptor of intercellular signals in several Drosophila developmental processes. Two other transmembrane proteins, encoded by the genes Delta and Serrate, genetically and molecularly behave as Notch ligands. All these proteins share the presence of epidermal growth factor (EGF)-like repeats in their extracellular domain. The Notch protein has 36 EGF-like repeats, 2 of which, numbers 11 and 12, are required for the interaction with the Delta and Serrate ligands. We have isolated and molecularly characterized a Notch mutation in its Delta- and Serrate-binding domain that behaves genetically as both a Notch antimorphic and a loss-of-function mutation. This mutation, NM1, carries a Glu-->Val substitution in the Notch EGF repeat 12. The NM1 allele interacts with other Notch alleles such as Abruptex and split and with mutations in the Notch-ligand genes Delta and Serrate. The basis for the genetic antimorphism of NM1 seems to reside in the titration of Notch wild-type products into NM1/N+ nonfunctional dimers and/or the titration of Delta products into nonfunctional ligand-receptor complexes.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Drosophila Genetics Insect Hormones Membrane Proteins Mutation Animals Anatomy & Histology Drosophila Proteins Epidermal Growth Factor Genes, Suppressor Genetic Complementation Test Molecular Sequence Data Oligodeoxyribonucleotides Phenotype Polymerase Chain Reaction Polymorphism, Genetic Receptors, Notch Repetitive Sequences, Nucleic Acid Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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