NDLI: Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

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Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, W. Pacini, S. Lienhard, G. E. Gutkind, J. S. White, M. F. Keegan, A. D. Wang, L. M. Myers, M. G. Sun, X. J. Aaronson, S. A.
Description	Author Affiliation: Wang LM ( Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.);
Abstract	Interleukin 4 (IL-4), insulin, and insulin-like growth factor I (IGF-I) efficiently induced DNA synthesis in the IL-3-dependent murine myeloid cell lines FDC-P1 and FDC-P2. Although these factors could not individually sustain long-term growth of these lines, a combination of IL-4 with either insulin or IGF-I did support continuous growth. The principal tyrosine-phosphorylated substrate observed in FDC cells stimulated with IL-4, previously designated 4PS, was of the same size (170 kDa) as the major substrate phosphorylated in response to insulin or IGF-I. These substrates had phosphopeptides of the same size when analyzed by digestion with Staphylococcus aureus V8 protease, and each tightly associated with the 85-kDa component of phosphatidylinositol 3-kinase after factor stimulation. IRS-1, the principal substrate phosphorylated in response to insulin or IGF-I stimulation in nonhematopoietic cells, is similar in size to 4PS. However, anti-IRS-1 antibodies failed to efficiently precipitate 4PS, and some phosphopeptides generated by V8 protease digestion of IRS-1 were distinct in size from the phosphopeptides of 4PS. Nevertheless, IL-4, insulin, and IGF-I were capable of stimulating tyrosine phosphorylation of IRS-1 in FDC cells that expressed this substrate as a result of transfection. These findings indicate that (i) IL-4, insulin, and IGF-I use signal transduction pathways in FDC lines that have at least one major feature in common, the rapid tyrosine phosphorylation of 4PS, and (ii) insulin and IGF-I stimulation of hematopoietic cell lines leads to the phosphorylation of a substrate that may be related to but is not identical to IRS-1.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Division Drug Effects DNA Replication Insulin Pharmacology Interleukin-4 Phosphoproteins Metabolism Signal Transduction Animals Blood Cells CHO Cells Cell Line Cricetinae Culture Media, Serum-Free Electrophoresis, Polyacrylamide Gel Insulin-Like Growth Factor I Interleukin-3 Kinetics Mice Peptide Mapping Phosphatidylinositol 3-Kinases Isolation & Purification Phosphotransferases Phosphotyrosine Receptor, Insulin Recombinant Proteins Thymidine Transfection Tyrosine Analogs & Derivatives Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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