NDLI: Retrotransposon insertion induces an isozyme of sn-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster.

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Retrotransposon insertion induces an isozyme of sn-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster.

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Retrotransposon insertion induces an isozyme of sn-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wilanowski, T. M. Symonds, J. E. Gibson, J. B.
Description	Author Affiliation: Wilanowski TM ( Molecular and Population Genetics Group, Research School of Biological Sciences, Australian National University, Canberra, Australia.);
Abstract	The insertion of the blood retrotransposon into the untranslated region of exon 7 of the sn-glycerol-3-phosphate dehydrogenase-encoding gene (Gpdh) in Drosophila melanogaster induces a GPDH isozyme-GPDH-4-and alters the pattern of expression of the three normal isozymes-GPDH-1 to GPDH-3. The process of transcript terminus formation inside the retrotransposon insertion reduces the level of the Gpdh transcript that contains exon 8 and increases the level of the transcript that contains exons 1-7. The induced GPDH-4 isozyme is a translation product of the three transcripts that contain fragments of the blood retrotransposon. The mechanism of mutagenesis by the blood insertion is postulated to involve the pause or termination of transcription within the blood sequence, which in turn is caused by the interference of a DNA-binding protein with the RNA polymerase. Thus, we show the formation of a new functional GPDH protein by the insertion of a transposable element and discuss the evolutionary significance of this phenomenon.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Drosophila Melanogaster Genetics Glycerolphosphate Dehydrogenase Biosynthesis Isoenzymes Retroelements Alleles Animals Biological Evolution Enzymology Enzyme Induction Exons Genes, Insect Molecular Sequence Data Mutagenesis, Insertional Oligodeoxyribonucleotides Polymerase Chain Reaction Repetitive Sequences, Nucleic Acid Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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