NDLI: Localization of the mRNA for a chicken prion protein by in situ hybridization.

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Localization of the mRNA for a chicken prion protein by in situ hybridization.

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Localization of the mRNA for a chicken prion protein by in situ hybridization.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Snider, W. D. Lele, P. Harris, D. A.
Description	Author Affiliation: Harris DA ( Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110.);
Abstract	The infectious agent (prion) responsible for transmissible spongiform encephalopathies in humans and animals is composed primarily of a 33- to 35-kDa glycoprotein called PrPSc (scrapie isoform of prion protein), which is a posttranslationally modified form of the normal cell-surface protein PrPC. Little is known about the function of PrPC. Interestingly, chPrP, the chicken homologue of PrPC, copurifies with a factor from brain that stimulates synthesis of acetylcholine receptors on skeletal muscle cells. Using in situ hybridization, we report here that chPrP mRNA is widely distributed in cholinergic and noncholinergic neurons throughout the adult central nervous system, including those in the telencephalic striata, thalamus and hypothalamus, optic tectum, medulla, cerebellum, and spinal cord. The mRNA is present in the brain and spinal cord as early as embryonic day 6 and is also found in dorsal root ganglia, retina, intestine, and heart. Our data suggest that if chPrP serves to regulate acetylcholine receptor number on postsynaptic targets, this is not its only function. It is likely that the protein plays a more widespread role in the central nervous system and perhaps elsewhere, possibly one related to intercellular communication, adhesion, or recognition. The chicken embryo represents an attractive experimental system in which to investigate the normal developmental function of PrPC.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Brain Physiology Prions Genetics RNA, Messenger Spinal Cord Animals Antisense Elements (Genetics) Cytology Cerebellum Chick Embryo Diencephalon In Situ Hybridization Medulla Oblongata RNA Probes Superior Colliculi Telencephalon Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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