NDLI: Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1993 Volume: 90 Issue: 24

Year: 1993 Volume: 90 Issue: 23

Year: 1993 Volume: 90 Issue: 22

Year: 1993 Volume: 90 Issue: 21

Year: 1993 Volume: 90 Issue: 20

Year: 1993 Volume: 90 Issue: 19

Year: 1993 Volume: 90 Issue: 18

Year: 1993 Volume: 90 Issue: 17

Year: 1993 Volume: 90 Issue: 16

Year: 1993 Volume: 90 Issue: 15

Year: 1993 Volume: 90 Issue: 14

Year: 1993 Volume: 90 Issue: 13

Year: 1993 Volume: 90 Issue: 12

Year: 1993 Volume: 90 Issue: 11

Year: 1993 Volume: 90 Issue: 10

Year: 1993 Volume: 90 Issue: 9

Global solutions of the equations of elastodynamics of incompressible neo-Hookean materials.

Photoreceptor twist: a solution to the false-color problem.

Molecular diversity of Ca2+ channel alpha 1 subunits from the marine ray Discopyge ommata.

CD43, the major sialoglycoprotein of human leukocytes, is proteolytically cleaved from the surface of stimulated lymphocytes and granulocytes.

Sequence-specific recognition of double helical RNA and RNA.DNA by triple helix formation.

Expression of the Xenopus laevis prolactin and thyrotropin genes during metamorphosis.

Evidence for virus-encoded glycosylation specificity.

Purification of a galanin receptor from pig brain.

Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2).

Vascular cell adhesion molecule 1: contrasting transcriptional control mechanisms in muscle and endothelium.

Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.

Oltipraz, an inhibitor of human immunodeficiency virus type 1 replication.

High-resolution mapping of the HyHEL-10 epitope of chicken lysozyme by site-directed mutagenesis.

Ligand-dependent transformation by the receptor for human granulocyte/macrophage colony-stimulating factor and tyrosine phosphorylation of the receptor beta subunit.

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells.

Epitope-tagged Gq alpha subunits: expression of GTPase-deficient alpha subunits persistently stimulates phosphatidylinositol-specific phospholipase C but not mitogen-activated protein kinase activity regulated by the M1 muscarinic acetylcholine receptor.

Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B.

Transcriptional activation of low density lipoprotein receptor gene by angiotensin-converting enzyme inhibitors and Ca(2+)-channel blockers involves protein kinase C isoforms.

Expression of functional hepatitis B virus polymerase in yeast reveals it to be the sole viral protein required for correct initiation of reverse transcription.

Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the gamma chain in two distinct signaling pathways.

Human monoclonal antibodies against a plethora of viral pathogens from single combinatorial libraries.

Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas.

Images of evolution: origin of spontaneous RNA replication waves.

Sequence-specific scission of DNA by the chemical nuclease activity of 1,10-phenanthroline-copper(I) targeted by RNA.

Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 differentiate it from the brain/gut receptor.

A Drosophila G-protein alpha subunit, Gf alpha, expressed in a spatially and temporally restricted pattern during Drosophila development.

Stimulation by phospholipids of a protein-tyrosine-phosphatase containing two src homology 2 domains.

Expression of complete keratin filaments in mouse L cells augments cell migration and invasion.

Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor beta in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation.

Protein kinase A activation of glucocorticoid-mediated signaling in the developing retina.

Indirect autoregulation of a homeotic Drosophila gene mediated by extracellular signaling.

A polypeptide bound by the chaperonin groEL is localized within a central cavity.

Opiate receptor agonists regulate phosphorylation of synapsin I in cocultures of rat spinal cord and dorsal root ganglion.

Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain.

Isolation and sequence of a cDNA encoding the Jerusalem artichoke cinnamate 4-hydroxylase, a major plant cytochrome P450 involved in the general phenylpropanoid pathway.

Loss of function of the Drosophila zfh-1 gene results in abnormal development of mesodermally derived tissues.

Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter.

Restrictions on the use of antigenic peptides by the immune system.

Induction of DNA rearrangement and transposition.

External GTP alters the motility and elicits an oscillating membrane depolarization in Paramecium tetraurelia.

A bacterially expressed single-chain Fv construct from the 2B4 T-cell receptor.

Retroviral insertions into a herpesvirus are clustered at the junctions of the short repeat and short unique sequences.

Retinoic acid is a negative regulator of the Epstein-Barr virus protein (BZLF1) that mediates disruption of latent infection.

Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic neurons.

A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer.

Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene.

Evidence that the putative COOH-terminal signal transamidase involved in glycosylphosphatidylinositol protein synthesis is present in the endoplasmic reticulum.

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

Morphologic and antigenic characterization of interferon gamma-mediated persistent Chlamydia trachomatis infection in vitro.

Thymidine kinase mutants obtained by random sequence selection.

A protein phosphatase related to the vaccinia virus VH1 is encoded in the genomes of several orthopoxviruses and a baculovirus.

The TFIIIB-assembling subunit of yeast transcription factor TFIIIC has both tetratricopeptide repeats and basic helix-loop-helix motifs.

Inhibition of a reductive function of the plasma membrane by bacitracin and antibodies against protein disulfide-isomerase.

Crystal structure of a ubiquitin-dependent degradation substrate: a three-disulfide form of lysozyme.

Rates of spontaneous mutation among RNA viruses.

Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors.

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry.

Atomic force microscopy of biochemically tagged DNA.

Actin is a surface component of calf pulmonary artery endothelial cells in culture.

Assembly of cartilage collagen fibrils is disrupted by overexpression of normal type II collagen in transgenic mice.

Predicting protein diffusion coefficients.

Synthesis of (1-->3), (1-->4)-beta-D-glucan in the Golgi apparatus of maize coleoptiles.

Long-term treatment of human immunodeficiency virus-infected cells with antisense oligonucleotide phosphorothioates.

Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters.

Initial localization of regulatory regions of the cardiac sarcolemmal Na(+)-Ca2+ exchanger.

Biochemical interaction of the Escherichia coli RecF, RecO, and RecR proteins with RecA protein and single-stranded DNA binding protein.

A single protein catalyzes both N-deacetylation and N-sulfation during the biosynthesis of heparan sulfate.

Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury.

Tandem double CC-->TT mutations are produced by reactive oxygen species.

Mice lacking major histocompatibility complex class I and class II molecules.

Histone H1 deposition and histone-DNA interactions in replicating chromatin.

In vivo expression of mutant preproendothelins: hierarchy of processing events but no strict requirement of Trp-Val at the processing site.

Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis?

Evidence from in vitro replication that O6-methylguanine can adopt multiple conformations.

Missense mutations in the beta-myosin heavy-chain gene cause central core disease in hypertrophic cardiomyopathy.

Assembly of pericellular matrices by COS-7 cells transfected with CD44 lymphocyte-homing receptor genes.

Increasing the chemical potential of the germ-line antibody repertoire.

Characterization of the rat neutral and basic amino acid transporter utilizing anti-peptide antibodies.

Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila.

Arachidonic acid stimulates glucose uptake in cerebral cortical astrocytes.

Cell type-preferred expression of maize cab-m1: repression in bundle sheath cells and enhancement in mesophyll cells.

Saturation mutagenesis of the human interleukin 6 receptor-binding site: implications for its three-dimensional structure.

Photoisomerization mechanism of the rhodopsin chromophore: picosecond photolysis of pigment containing 11-cis-locked eight-membered ring retinal.

Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex.

Body size, metabolic rate, generation time, and the molecular clock.

Coevolution of persistently infecting small DNA viruses and their hosts linked to host-interactive regulatory domains.

Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration.

Recombination sequence-binding protein in thymocytes undergoing T-cell receptor gene rearrangement.

Gene inoculation generates immune responses against human immunodeficiency virus type 1.

Translation of mRNAs with degenerate initiation triplet AUU displays high initiation factor 2 dependence and is subject to initiation factor 3 repression.

Controlled release of polypeptides from polyanhydrides.

Interaction of translation factor SELB with the formate dehydrogenase H selenopolypeptide mRNA.

Proposed atomic structure of a truncated human immunodeficiency virus glycoprotein gp120 derived by molecular modeling: target CD4 recognition and docking mechanism.

Cloning and characterization of a fourth human somatostatin receptor.

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

Functional replacement of the hemolysin A transport signal by a different primary sequence.

Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.

Mapping the determinants of human immunodeficiency virus 2 for infectivity, replication efficiency, and cytopathicity.

DNA sequencing: modular primers assembled from a library of hexamers or pentamers.

Additivity of mutant effects assessed by binomial mutagenesis.

Low density lipoprotein- and high density lipoprotein-mediated signal transduction and exocytosis in alveolar type II cells.

Transmission-blocking activity of a chitinase inhibitor and activation of malarial parasite chitinase by mosquito protease.

Three-dimensional structure of a human immunoglobulin with a hinge deletion.

Associative learning potentiates protein kinase C activation in synaptosomes of the rabbit hippocampus.

Dexamethasone negatively regulates the activity of a chimeric dihydrofolate reductase/glucocorticoid receptor protein.

PutA protein, a membrane-associated flavin dehydrogenase, acts as a redox-dependent transcriptional regulator.

Two Neurospora mitochondrial plasmids encode DNA polymerases containing motifs characteristic of family B DNA polymerases but lack the sequence Asp-Thr-Asp.

Localization of the mRNA for a chicken prion protein by in situ hybridization.

Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

Analysis of pyruvate kinase-deficiency mutations that produce nonspherocytic hemolytic anemia.

Year: 1993 Volume: 90 Issue: 8

Year: 1993 Volume: 90 Issue: 7

Year: 1993 Volume: 90 Issue: 6

Year: 1993 Volume: 90 Issue: 5

Year: 1993 Volume: 90 Issue: 4

Year: 1993 Volume: 90 Issue: 3

Year: 1993 Volume: 90 Issue: 2

Year: 1993 Volume: 90 Issue: 1

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Flavell, R. A. Fikrig, E. Barthold, S. W. Kantor, F. S. Tao, H.
Description	Author Affiliation: Fikrig E ( Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510.);
Abstract	We analyzed variability in outer surface protein B (OspB) from Borrelia burgdorferi (Bb), the causative agent of Lyme disease, to determine how Bb escapes immune destruction. We have shown that vaccination with OspB from Bb strain B31 protected mice from infection with Bb B31 but not against Bb N40. The present study demonstrates that Bb N40 spirochetes which evade vaccination immunity to OspB have a truncated form of OspB, due to a TAA stop codon at nucleotide 577. In contrast, Bb N40 spirochetes that express full-length OspB are unable to infect mice immunized with OspB, analogous to our previous studies with Bb B31. Mapping of the OspB antibody response shows that epitopes in the C terminus of OspB are surface-exposed and bind protective monoclonal and polyclonal antibodies. This suggests that the C terminus of OspB is important for eliciting a protective immune response to OspB. Truncation or modification of outer surface proteins that do not bind protective antibody may be a means by which Bb evades host defenses.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Bacterial Antigens, Surface Immunology Bacterial Outer Membrane Proteins Borrelia Burgdorferi Group Lyme Disease Amino Acid Sequence Animals Antibodies Antibodies, Monoclonal Biosynthesis Genetics Cloning, Molecular Codon Epitopes Escherichia Coli Fluorescent Antibody Technique Genes, Bacterial Prevention & Control Mice Mice, Inbred C3H Polymerase Chain Reaction Recombinant Fusion Proteins Recombinant Proteins Restriction Mapping Microbiology Vaccines, Synthetic Viral Vaccines Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in