NDLI: Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas.

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Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Papas, T. S. Henderson, K. W. Suster, S. Schweinfest, C. W. Kondoh, N.
Description	Author Affiliation: Schweinfest CW ( Laboratory of Molecular Oncology, National Cancer Institute, Frederick, MD 21702-1201.);
Abstract	A cDNA, which we call DRA (for down-regulated in adenoma) has been isolated. Its mRNA is expressed exclusively in normal colon tissue, probably only in the mucosal epithelia. Expression of the DRA gene is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. The DRA gene appears to be a single-copy gene present on chromosome 7, a chromosome associated with colorectal tumorigenesis. The predicted DRA polypeptide is an 84,500-Da protein that contains charged clusters of amino acids, primarily at the NH2 and COOH termini. Together with potential nuclear targeting motifs, an acidic transcriptional activation domain, and a homeobox domain, these elements suggest a transcription factor or a protein that may interact with transcription factors. Such a function may be consistent with a role in tissue-specific gene expression and/or as a candidate tumor-suppressor gene.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenocarcinoma Genetics Adenoma Antiporters Carrier Proteins Colon Physiology Colonic Neoplasms Colonic Polyps DNA, Neoplasm DNA Genes, Tumor Suppressor Intestinal Mucosa Membrane Proteins Proteins Amino Acid Sequence Cells, Cultured Chloride-Bicarbonate Antiporters Chromosome Mapping Isolation & Purification Gene Library Genes, Homeobox Molecular Sequence Data Multigene Family Polymerase Chain Reaction Metabolism RNA RNA, Messenger RNA, Neoplasm Sequence Homology, Amino Acid Transcription Factors Comparative Study Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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