NDLI: Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.

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Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.

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Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Flavell, R. A. Fikrig, E. Telford, S. R. Barthold, S. W. Spielman, A. Kantor, F. S.
Description	Author Affiliation: Fikrig E ( Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.);
Abstract	Although recombinant outer surface protein A (OspA) of Borrelia burgdorferi protects mice against injected Lyme disease spirochetes, the mode of protection has not yet been explored. Indeed, the efficacy of vaccine-induced immunity against a realistic vector-mediated challenge remains unexplored. Accordingly, we determined whether this immunogen protects mice against spirochetes delivered by nymphal Ixodes dammini ticks. Following challenge by tick bite, no spirochetes could be cultured from immunized mice, and no characteristic histopathology was found. The spirochete was not detected in ticks that fed on immunized animals and was present in virtually all ticks that fed on nonimmunized mice. We conclude that OspA-immunized mice are protected from spirochetal infection, at least in part, because the spirochete is destroyed in the infecting tick.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	12
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Surface Immunology Bacterial Outer Membrane Proteins Bacterial Proteins Bacterial Vaccines Administration & Dosage Borrelia Burgdorferi Group Lipoproteins Lyme Disease Microbiology Animals Genetics Growth & Development Fluorescent Antibody Technique Pathology Mice Mice, Inbred C3H Recombinant Fusion Proteins Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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