NDLI: Nuclear localization signals also mediate the outward movement of proteins from the nucleus.

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Nuclear localization signals also mediate the outward movement of proteins from the nucleus.

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Impact melting of frozen oceans on the early Earth: Implications for the origin of life

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Nuclear localization signals also mediate the outward movement of proteins from the nucleus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lescop, P. Guiochon-mantel, A. Milgrom, E. Delabre, K.
Description	Author Affiliation: Guiochon-Mantel A ( Institut National de la Santé et de la Recherche Médicale, Unité 135, Hormones et Reproduction, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.);
Abstract	Several nuclear proteins, including steroid hormone receptors, have been shown to shuttle continuously between the nucleus and the cytoplasm. The mechanism of entry of proteins into the nucleus is well documented, whereas the mechanism of their outward movement into the cytoplasm is not understood. We have grafted the nuclear localization signals of the progesterone receptor or the simian virus 40 large tumor antigen onto beta-galactosidase. These additions were shown to impart to the protein the ability to shuttle between the nucleus and the cytoplasm. Microinjected proteins devoid of a nuclear localization signal were unable to exit from the nucleus. The same nuclear localization signals are thus involved in both the inward and the outward movement of proteins through the nuclear membrane. We also show that although the nuclear import requires energy, the nuclear export does not. These results suggest that the nucleocytoplasmic shuttling may be a general phenomenon for nuclear proteins that could possibly undergo modifications in the cytoplasm and exert some biological activities there. These conclusions also imply that at least part of the cellular machinery involved in the nuclear import of proteins may function bidirectionally.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Polyomavirus Transforming Metabolism Cell Nucleus Protein Sorting Signals Receptors, Progesterone Amino Acid Sequence Animals Biological Transport Cell Line Cloning, Molecular Cytoplasm Cytosol Fluorescent Antibody Technique Haplorhini L Cells (Cell Line) Mice Molecular Sequence Data Recombinant Fusion Proteins Beta-Galactosidase Genetics Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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